Calcium glycerophosphate is an medication used to treat low levels of phosphate or calcium, as well as an ingredient in dental products to prevent dental caries. Calcium glycerophosphate is a DB01373 salt of glycerophosphoric acid that forms a white, fine, slightly hygroscopic powder.
- Mechanism
- Curator reviewed · 4 references
Calcium glycerophosphate in combination with sodium monofluorophosphate was found to reduce the acid solubility of enamel. This is thought to be due to increased uptake of fluoride in a non-alkali soluble form at the expense of a fraction remaining in the alkali-soluble form of calcium fluoride. It is also thought that calcium glycerophosphate enhances the remineralization effect of sodium monofluorophosphate leading to greater remineralization of enamel but the mechanism behind this is unknown.
Calcium glycerophosphate reduces the decrease in plaque pH produced by sucrose solutions. This may be due to the buffering action of donated phosphate which acts as an acceptor to three hydrogen ions to form biphosphate, dihydrogen phosphate, and finally phosphoric acid. As bisphosphate and dihydrogen phosphate are amphoteric, these molecules can act as buffers against both acids and bases.
Studies on plaque-modification by calcium glycerophosphate have been inconsistent. Redections in plaque weight and plaque area have been noted in separate studies but neither has been confirmed and no causative link has been established in regards to calcium glycerophosphate's anti-caries effect.
Calcium glycerophosphate donates DB01373 and inorganic phosphate resulting in elevated levels of the ions in plaque. These ions are important components of the mineral structure of teeth. As such, their presence supports maintenance of healthy tooth structure and mineralization.
In electrolyte replacement calcium glycerophosphate again acts as a donor of DB01373 and phosphate. See DB11348 for pharmacological descriptions of calcium and phosphate.
- Primary indication
- Calcium glycerophosphate is found in OTC dental products such as toothpastes for the prevention of dental caries.Curator reviewed
- Formula / weight
- C3H7CaO6P · 210.135 g/mol (avg)
- First approval
- Canada, 1997
- Also known as
- Calcium beta-glycerophosphate
Resolves to
UHHRFSOMMCWGSO-UHFFFAOYSA-LSMILES[Ca++].OCC(CO)OP([O-])([O-])=OWhat you can answer from here — as of July 19, 2026
Which companies are running trials of Calcium glycerophosphate, in which indications and phases, and which of those programs are still active?
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