Alfaxalone

DB11371ExperimentalVet approvedSmall molecule

Alfaxalone, also known as alphaxalone or alphaxolone, is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use... Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin.

Mechanism: Pharmacologically active on GABA(A) Receptor
Curator reviewed
Formula / weight: C₂₁H₃₂O₃ · 332.484 g/mol (avg)
Code names: GR-2/234

Resolves to

Compound

UNIIBD07M97B2ACAS23930-19-0ChEMBLCHEMBL190279ChEBI34531PubChem104845KEGGD07282

Clinical / RWD

RxNorm1544577ATCN01AX05

Structure

InChIKeyDUHUCHOQIDJXAT-OLVMNOGESA-NSMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@]([H])(O)CC[C@]4(C)[C@@]3([H])C(=O)C[C@]12C)C(C)=O

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

670Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 9 drug categories

12+ReferencesStructured and connected to the statements they support

Which companies are running trials of Alfaxalone, in which indications and phases, and which of those programs are still active?

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