Decoquinate
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Decoquinate
- DrugBank Accession Number
- DB11394
- Background
Decoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites.
- Type
- Small Molecule
- Groups
- Experimental, Vet approved
- Structure
- Weight
- Average: 417.546
Monoisotopic: 417.251523231 - Chemical Formula
- C24H35NO5
- Synonyms
- Decoquinate
- Decoquinato
- Decoquinatum
- External IDs
- HC 1528
- HC-1528
- M&B 15497
- M&B-15497
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Deccox
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as hydroquinolones. These are compounds containing a hydrogenated quinoline bearing a ketone group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Quinolines and derivatives
- Sub Class
- Quinolones and derivatives
- Direct Parent
- Hydroquinolones
- Alternative Parents
- Hydroquinolines / Pyridinecarboxylic acids / Alkyl aryl ethers / Benzenoids / Vinylogous amides / Heteroaromatic compounds / Carboxylic acid esters / Monocarboxylic acids and derivatives / Azacyclic compounds / Organopnictogen compounds show 3 more
- Substituents
- Alkyl aryl ether / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Carboxylic acid derivative / Carboxylic acid ester / Dihydroquinoline / Dihydroquinolone / Ether / Heteroaromatic compound show 12 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 534I52PVWH
- CAS number
- 18507-89-6
- InChI Key
- JHAYEQICABJSTP-UHFFFAOYSA-N
- InChI
- InChI=1S/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26)
- IUPAC Name
- ethyl 6-(decyloxy)-7-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
- SMILES
- CCCCCCCCCCOC1=C(OCC)C=C2NC=C(C(=O)OCC)C(=O)C2=C1
References
- General References
- Authors unspecified: The determination of decoquinate in animal feeds. Analyst. 1975 Jan;100(1186):63-7. [Article]
- Hobson-Frohock A: Determination of decoquinate in poultry feed. Analyst. 1982 Oct;107(1279):1195-9. [Article]
- Filer CW, Hiscock DR, Parnell EW: Decoquinate. I. An absorption and elimination study in broiler chickens using 14C-labelled decoquinate. J Sci Food Agric. 1969 Feb;20(2):65-9. [Article]
- McLoughlin DK, Chute MB: Efficacy of decoquinate against eleven strains of Eimeria tenella and development of a decoquinate-resistant strain. Avian Dis. 1971 Apr-Jun;15(2):342-5. [Article]
- Lindsay DS, Butler JM, Blagburn BL: Efficacy of decoquinate against Neospora caninum tachyzoites in cell cultures. Vet Parasitol. 1997 Jan;68(1-2):35-40. [Article]
- Seman DH, Hayek MG, Batson DB, Cantor AH, Tucker RE, Muntifering RB, Ely DG, Soler BL, Mitchell GE Jr: Comparative metabolism of 14C-decoquinate in chickens, quail and sheep. Vet Hum Toxicol. 1986 Aug;28(4):325-7. [Article]
- Foreyt WJ, Hancock D, Wescott RB: Prevention and control of coccidiosis in goats with decoquinate. Am J Vet Res. 1986 Feb;47(2):333-5. [Article]
- Seman DH, Catherman DR, Matsui T, Hayek MG, Batson DB, Cantor AH, Tucker RE, Muntifering RB, Westendorf ML, Mitchell GE Jr: Metabolism of decoquinate in chickens and Japanese quail. Poult Sci. 1989 May;68(5):670-5. [Article]
- Miner ML, Jensen JB: Decoquinate in the control of experimentally induced coccidiosis of calves. Am J Vet Res. 1976 Sep;37(9):1043-5. [Article]
- Quintero-de Leonardo J, Rosiles R, Bautista J, Gonzalez-Monson N, Sumano H: Oral pharmacokinetics and milk residues of decoquinate in milking cows. J Vet Pharmacol Ther. 2009 Aug;32(4):403-6. doi: 10.1111/j.1365-2885.2008.01049.x. [Article]
- External Links
- KEGG Drug
- D03667
- ChemSpider
- 27081
- 1314345
- ChEMBL
- CHEMBL416230
- ZINC
- ZINC000038139853
- Wikipedia
- Decoquinate
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Powder - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000679 mg/mL ALOGPS logP 6 ALOGPS logP 6.31 Chemaxon logS -5.8 ALOGPS pKa (Strongest Acidic) 5.95 Chemaxon pKa (Strongest Basic) -1.5 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 73.86 Å2 Chemaxon Rotatable Bond Count 15 Chemaxon Refractivity 119.77 m3·mol-1 Chemaxon Polarizability 49.91 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 227.4916695 predictedDarkChem Lite v0.1.0 [M-H]- 208.78835 predictedDeepCCS 1.0 (2019) [M+H]+ 229.0889695 predictedDarkChem Lite v0.1.0 [M+H]+ 212.44356 predictedDeepCCS 1.0 (2019) [M+Na]+ 228.1722695 predictedDarkChem Lite v0.1.0 [M+Na]+ 221.25862 predictedDeepCCS 1.0 (2019)
Drug created at February 25, 2016 18:22 / Updated at February 21, 2021 18:53