NAV

Famphur

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Famphur
Accession Number
DB11408
Description
Not Available
Type
Small Molecule
Groups
Vet approved
Structure
Thumb
3D
Similar Structures
Weight
Average: 325.33
Monoisotopic: 325.020751965
Chemical Formula
C10H16NO5PS2
Synonyms
  • Famophos
  • O-[4-(dimethylsulfamoyl)phenyl] O,O-dimethyl thiophosphate
  • Phosphorothioic acid, O-(4-((dimethylamino)sulfonyl)phenyl) O,O-dimethyl ester

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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AcebutololThe risk or severity of QTc prolongation can be increased when Famphur is combined with Acebutolol.
AcrivastineThe risk or severity of QTc prolongation can be increased when Acrivastine is combined with Famphur.
AdenosineThe risk or severity of QTc prolongation can be increased when Famphur is combined with Adenosine.
AjmalineThe risk or severity of QTc prolongation can be increased when Ajmaline is combined with Famphur.
AlfuzosinThe risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Famphur.
AlimemazineThe risk or severity of QTc prolongation can be increased when Alimemazine is combined with Famphur.
AmantadineThe risk or severity of QTc prolongation can be increased when Amantadine is combined with Famphur.
AmifampridineThe risk or severity of QTc prolongation can be increased when Famphur is combined with Amifampridine.
AmiodaroneThe risk or severity of QTc prolongation can be increased when Famphur is combined with Amiodarone.
AmisulprideThe risk or severity of QTc prolongation can be increased when Amisulpride is combined with Famphur.
Additional Data Available
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    Extended Description
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  • Severity
    Severity
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    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level
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  • Action
    Action
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenyl thiophosphates. These are organothiophosphorus compounds that contain a thiophosphoric acid O-esterified with a phenyl group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic thiophosphoric acids and derivatives
Sub Class
Thiophosphoric acid esters
Direct Parent
Phenyl thiophosphates
Alternative Parents
Benzenesulfonamides / Benzenesulfonyl compounds / Thiophosphate triesters / Phenoxy compounds / Organosulfonamides / Aminosulfonyl compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides
show 1 more
Substituents
Aminosulfonyl compound / Aromatic homomonocyclic compound / Benzenesulfonamide / Benzenesulfonyl group / Benzenoid / Hydrocarbon derivative / Monocyclic benzene moiety / Organic nitrogen compound / Organic oxide / Organic oxygen compound
show 11 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
organic thiophosphate, organothiophosphate insecticide (CHEBI:38677) / Organophosphorus insecticides (C18658)

Chemical Identifiers

UNII
02UOP4Z0O0
CAS number
52-85-7
InChI Key
JISACBWYRJHSMG-UHFFFAOYSA-N
InChI
InChI=1S/C10H16NO5PS2/c1-11(2)19(12,13)10-7-5-9(6-8-10)16-17(18,14-3)15-4/h5-8H,1-4H3
IUPAC Name
O-4-(dimethylsulfamoyl)phenyl O,O-dimethyl phosphorothioate
SMILES
COP(=S)(OC)OC1=CC=C(C=C1)S(=O)(=O)N(C)C

References

General References
  1. Franson JC, Kolbe EJ, Carpenter JW: Famphur toxicosis in a bald eagle. J Wildl Dis. 1985 Jul;21(3):318-20. [PubMed:4032636]
  2. Cummins LJ: Cow fertility after lice treatment with famphur. Aust Vet J. 1977 Apr;53(4):200. [PubMed:869822]
  3. Cummins LJ: Cow fertility after lice treatment with famphur. Aust Vet J. 1977 Aug;53(8):406-7. [PubMed:588171]
  4. Johnson WP, Alford BT, Drain JJ: Safety of famphur to young Brahman heifers, bulls and steers. Vet Med Small Anim Clin. 1972 Jun;67(6):686. [PubMed:4483149]
  5. Erne K, Nordkvist M: The disappearance rate in reindeer of famphur an organophosphorus parasiticide. Acta Vet Scand. 1970;11(2):209-18. [PubMed:5465142]
  6. Randell WF, Bradley RE: Effects of injectable famphur on young Brahman and Angus cattle. Am J Vet Res. 1980 Sep;41(9):1423-6. [PubMed:7447135]
  7. Ivey MC: Gas-liquid chromatographic determination of famphur and its oxygen analog in tissues of reindeer and cattle. J Assoc Off Anal Chem. 1976 Mar;59(2):261-3. [PubMed:1254545]
  8. Watson K, Black WD: Whole blood cholinesterase activity in calves after topical treatment with famphur. Can Vet J. 1981 Jun;22(6):179-81. [PubMed:7284948]
  9. White DH, Hayes LE, Bush PB: Case histories of wild birds killed intentionally with famphur in Georgia and West Virginia. J Wildl Dis. 1989 Apr;25(2):184-8. [PubMed:2716098]
  10. Felton CL, Brown PM, Fletcher MR, Stanley PI, Quick MP, Machin AF: Bird poisoning following the use of warble fly treatments containing famphur. Vet Rec. 1981 May 16;108(20):440. [PubMed:7292913]
KEGG Compound
C18658
ChemSpider
5650
ChEBI
38677
ChEMBL
CHEMBL1525287
ZINC
ZINC000002041376

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.229 mg/mLALOGPS
logP2.15ALOGPS
logP1.71ChemAxon
logS-3.2ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area65.07 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity77.82 m3·mol-1ChemAxon
Polarizability29.65 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on February 25, 2016 11:28 / Updated on June 12, 2020 10:53

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