Famphur
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Famphur
- Accession Number
- DB11408
- Description
- Not Available
- Type
- Small Molecule
- Groups
- Vet approved
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Learn More- Structure
Structure for Famphur (DB11408)
- Weight
- Average: 325.33
Monoisotopic: 325.020751965 - Chemical Formula
- C10H16NO5PS2
- Synonyms
- Famophos
- O-[4-(dimethylsulfamoyl)phenyl] O,O-dimethyl thiophosphate
- Phosphorothioic acid, O-(4-((dimethylamino)sulfonyl)phenyl) O,O-dimethyl ester
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAcebutolol The risk or severity of QTc prolongation can be increased when Famphur is combined with Acebutolol. Acrivastine The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Famphur. Adenosine The risk or severity of QTc prolongation can be increased when Famphur is combined with Adenosine. Ajmaline The risk or severity of QTc prolongation can be increased when Ajmaline is combined with Famphur. Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Famphur. Alimemazine The risk or severity of QTc prolongation can be increased when Alimemazine is combined with Famphur. Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Famphur. Amifampridine The risk or severity of QTc prolongation can be increased when Famphur is combined with Amifampridine. Amiodarone The risk or severity of QTc prolongation can be increased when Famphur is combined with Amiodarone. Amisulpride The risk or severity of QTc prolongation can be increased when Amisulpride is combined with Famphur. Additional Data Available- Extended DescriptionExtended DescriptionAvailable for Purchase
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - SeveritySeverityAvailable for Purchase
A severity rating for each drug interaction, from minor to major.
Learn more - Evidence LevelEvidence LevelAvailable for Purchase
A rating for the strength of the evidence supporting each drug interaction.
Learn more - ActionActionAvailable for Purchase
An effect category for each drug interaction. Know how this interaction affects the subject drug.
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- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenyl thiophosphates. These are organothiophosphorus compounds that contain a thiophosphoric acid O-esterified with a phenyl group.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Organic thiophosphoric acids and derivatives
- Sub Class
- Thiophosphoric acid esters
- Direct Parent
- Phenyl thiophosphates
- Alternative Parents
- Benzenesulfonamides / Benzenesulfonyl compounds / Thiophosphate triesters / Phenoxy compounds / Organosulfonamides / Aminosulfonyl compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides show 1 more
- Substituents
- Aminosulfonyl compound / Aromatic homomonocyclic compound / Benzenesulfonamide / Benzenesulfonyl group / Benzenoid / Hydrocarbon derivative / Monocyclic benzene moiety / Organic nitrogen compound / Organic oxide / Organic oxygen compound show 11 more
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- organic thiophosphate, organothiophosphate insecticide (CHEBI:38677) / Organophosphorus insecticides (C18658)
Chemical Identifiers
- UNII
- 02UOP4Z0O0
- CAS number
- 52-85-7
- InChI Key
- JISACBWYRJHSMG-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H16NO5PS2/c1-11(2)19(12,13)10-7-5-9(6-8-10)16-17(18,14-3)15-4/h5-8H,1-4H3
- IUPAC Name
- O-4-(dimethylsulfamoyl)phenyl O,O-dimethyl phosphorothioate
- SMILES
- COP(=S)(OC)OC1=CC=C(C=C1)S(=O)(=O)N(C)C
References
- General References
- Franson JC, Kolbe EJ, Carpenter JW: Famphur toxicosis in a bald eagle. J Wildl Dis. 1985 Jul;21(3):318-20. [PubMed:4032636]
- Cummins LJ: Cow fertility after lice treatment with famphur. Aust Vet J. 1977 Apr;53(4):200. [PubMed:869822]
- Cummins LJ: Cow fertility after lice treatment with famphur. Aust Vet J. 1977 Aug;53(8):406-7. [PubMed:588171]
- Johnson WP, Alford BT, Drain JJ: Safety of famphur to young Brahman heifers, bulls and steers. Vet Med Small Anim Clin. 1972 Jun;67(6):686. [PubMed:4483149]
- Erne K, Nordkvist M: The disappearance rate in reindeer of famphur an organophosphorus parasiticide. Acta Vet Scand. 1970;11(2):209-18. [PubMed:5465142]
- Randell WF, Bradley RE: Effects of injectable famphur on young Brahman and Angus cattle. Am J Vet Res. 1980 Sep;41(9):1423-6. [PubMed:7447135]
- Ivey MC: Gas-liquid chromatographic determination of famphur and its oxygen analog in tissues of reindeer and cattle. J Assoc Off Anal Chem. 1976 Mar;59(2):261-3. [PubMed:1254545]
- Watson K, Black WD: Whole blood cholinesterase activity in calves after topical treatment with famphur. Can Vet J. 1981 Jun;22(6):179-81. [PubMed:7284948]
- White DH, Hayes LE, Bush PB: Case histories of wild birds killed intentionally with famphur in Georgia and West Virginia. J Wildl Dis. 1989 Apr;25(2):184-8. [PubMed:2716098]
- Felton CL, Brown PM, Fletcher MR, Stanley PI, Quick MP, Machin AF: Bird poisoning following the use of warble fly treatments containing famphur. Vet Rec. 1981 May 16;108(20):440. [PubMed:7292913]
- External Links
- KEGG Compound
- C18658
- ChemSpider
- 5650
- ChEBI
- 38677
- ChEMBL
- CHEMBL1525287
- ZINC
- ZINC000002041376
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.229 mg/mL ALOGPS logP 2.15 ALOGPS logP 1.71 ChemAxon logS -3.2 ALOGPS Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 65.07 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 77.82 m3·mol-1 ChemAxon Polarizability 29.65 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created on February 25, 2016 11:28 / Updated on June 12, 2020 10:53
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