Norgestomet
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Norgestomet
- DrugBank Accession Number
- DB11440
- Background
Norgestomet, also known as 11β-methyl-17-hydroxy-19-norprogesterone acetate, is a steroidal progestin used in veterinary medicine to control estrus and ovulation in cattle.
- Type
- Small Molecule
- Groups
- Vet approved
- Structure
- Weight
- Average: 372.505
Monoisotopic: 372.23005951 - Chemical Formula
- C23H32O4
- Synonyms
- Norgestomet
- External IDs
- SC-21009
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image แบ๊ทเทอร์ฟลาย Norgestomet (0.5 MG) + Ethinylestradiol (50 MCG) Tablet, sugar coated Oral บริษัท ไบร์วู๊ดฟาร์มาซูติคอล จำกัด 2001-06-30 Not applicable Thailand
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Pregnane steroids
- Direct Parent
- Gluco/mineralocorticoids, progestogins and derivatives
- Alternative Parents
- Steroid esters / 20-oxosteroids / 3-oxo delta-4-steroids / Delta-4-steroids / Cyclohexenones / Alpha-acyloxy ketones / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives
- Substituents
- 20-oxosteroid / 3-oxo-delta-4-steroid / 3-oxosteroid / Aliphatic homopolycyclic compound / Alpha-acyloxy ketone / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Cyclic ketone / Cyclohexenone
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 3L33UD42X4
- CAS number
- 25092-41-5
- InChI Key
- IWSXBCZCPVUWHT-VIFKTUCRSA-N
- InChI
- InChI=1S/C23H32O4/c1-13-12-22(4)20(9-10-23(22,14(2)24)27-15(3)25)19-7-5-16-11-17(26)6-8-18(16)21(13)19/h11,13,18-21H,5-10,12H2,1-4H3/t13-,18-,19-,20-,21+,22-,23-/m0/s1
- IUPAC Name
- (1R,3aS,3bR,9aR,9bS,10S,11aS)-1-acetyl-10,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
- SMILES
- [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)C[C@H](C)[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
References
- General References
- Kesler DJ: Norgestomet implants maintain pregnancy in ovariectomized heifers. Theriogenology. 1997 Jul 1;48(1):89-98. [Article]
- Drew SB, Wishart DF, Young IM: Fertility of norgestomet treated suckler cows. Vet Rec. 1979 Jun 9;104(23):523-5. [Article]
- Rao AR, Rao SV: Synchronisation of oestrus in buffaloes with norgestomet. Vet Rec. 1979 Sep 15;105(11):256. [Article]
- Wishart DF, Young IM, Drew SB: Fertility of norgestomet treated dairy heifers. Vet Rec. 1977 May 14;100(20):417-20. [Article]
- Geary TW, Reeves JJ, Schafer DW, Evans RR, Randel RD, Rutter LM, Sasser RG, Guardia R, Alexander B, Holcombe D, Hanks DR, Faulkner DB: Norgestomet implants prevent pregnancy in beef heifers on pasture. J Anim Sci. 1997 Dec;75(12):3089-93. [Article]
- Garcia-Winder M, Lewis PE, Townsend EC, Inskeep EK: Effects of norgestomet on follicular development in postpartum beef cows. J Anim Sci. 1987 Apr;64(4):1099-109. [Article]
- Carpenter RH, Spitzer JC: Response of anestrous ewes to norgestomet and PMSG. Theriogenology. 1981 Apr;15(4):389-93. [Article]
- Burns PD, Spitzer JC, Burns GL, Plyler BB: Inhibition of estrus and corpora lutea function with Norgestomet. Theriogenology. 1993 Apr;39(4):863-73. [Article]
- Moffatt RJ, Zollers WG Jr, Welshons WV, Kieborz KR, Garverick HA, Smith MF: Basis of norgestomet action as a progestogen in cattle. Domest Anim Endocrinol. 1993 Jan;10(1):21-30. [Article]
- Cardwell BE, Fitch GQ, Geisert RD: Ultrasonic evaluation for the time of ovulation in ewes treated with norgestomet and norgestomet followed by pregnant mare's serum gonadotropin. J Anim Sci. 1998 Sep;76(9):2235-8. [Article]
- External Links
- KEGG Drug
- D05210
- ChemSpider
- 7996587
- ChEMBL
- CHEMBL2104744
- ZINC
- ZINC000004217176
- Wikipedia
- Norgestomet
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, sugar coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00489 mg/mL ALOGPS logP 2.95 ALOGPS logP 3.83 Chemaxon logS -4.9 ALOGPS pKa (Strongest Acidic) 17.68 Chemaxon pKa (Strongest Basic) -4.7 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 60.44 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 103.33 m3·mol-1 Chemaxon Polarizability 42.06 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0a4i-0129000000-7c8ec1c1c033edadb3f6 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-00di-2009000000-b14cec15479eb735e7bc Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-6059000000-812eae92afe02bae8fde Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0005-0194000000-d4c714edb898139d3548 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-9000000000-98e53c3bbd42317f8921 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0096-1791000000-8555b0ab90df57d52c87 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 192.28914 predictedDeepCCS 1.0 (2019) [M+H]+ 194.18457 predictedDeepCCS 1.0 (2019) [M+Na]+ 200.38655 predictedDeepCCS 1.0 (2019)
Drug created at February 25, 2016 18:47 / Updated at February 21, 2021 18:53