Selamectin

DB11459ExperimentalVet approvedSmall molecule

Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in... It also removes 2 types of lungworm in cats and one type of lungworm in dogs.

Formula / weight: C₄₃H₆₃NO₁₁ · 769.973 g/mol (avg)
Code names: UK-124,114

Resolves to

Compound

UNIIA2669OWX9NCAS220119-17-5ChEMBLCHEMBL1908325

Clinical / RWD

RxNorm1044269

Structure

InChIKeyAFJYYKSVHJGXSN-XHKIUTQPSA-NSMILES

[H][C@@]12OC\C3=C/C=C/[C@H](C)[C@H](O[C@@]4([H])C[C@H](OC)[C@@H](O)[C@H](C)O4)\C(C)=C\C[C@]4([H])C[C@@]([H])(C[C@]5(CC[C@H](C)[C@]([H])(O5)C5CCCCC5)O4)OC(=O)[C@]([H])(C=C(C)\C1=N\O)[C@@]23O

Targets

Q5XXA6ANO1

Transporters

P08183ABCB1

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

317Drug interactionsStructured to mechanism, not free text

13+ReferencesStructured and connected to the statements they support

Which drugs share a target with Selamectin, and which of those have an active Phase 3 trial?

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