Hygromycin B

DB11520ExperimentalVet approvedSmall molecule

Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.

Mechanism: Pharmacologically active on Signal transducer and activator of transcription 3 and 16S ribosomal RNA
Curator reviewed
Formula / weight: C₂₀H₃₇N₃O₁₃ · 527.524 g/mol (avg)

Resolves to

Compound

UNII3XQ2233B0BCAS31282-04-9

Clinical / RWD

RxNorm1426887

Structure

InChIKeyGRRNUXAQVGOGFE-HUCHGKBZSA-NSMILES

[H][C@@]12OC3(O[C@]1([H])[C@H](O[C@]1([H])[C@@H](O)[C@H](N)C[C@H](NC)[C@H]1O)O[C@H](CO)[C@@H]2O)O[C@]([H])([C@@H](N)CO)[C@H](O)[C@H](O)[C@H]3O

Targets

P40763STAT3

What you can answer from here — as of July 09, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

877Drug interactionsStructured to mechanism, not free text

14+ReferencesStructured and connected to the statements they support

Which drugs share a target with Hygromycin B, and which of those have an active Phase 3 trial?

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