Bicuculline

DB11562ExperimentalSmall molecule

Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and...

Mechanism: Pharmacologically active on GABA(A) Receptor
Curator reviewed
Formula / weight: C₂₀H₁₇NO₆ · 367.3521 g/mol (avg)
Also known as: Bicculine · Bicucullin · d-Bicuculline

Resolves to

Compound

UNIIY37615DVKCCAS485-49-4ChEMBLCHEMBL417990ChEBI3092PubChem10237KEGGC09364

Structure

InChIKeyIYGYMKDQCDOMRE-ZWKOTPCHSA-NSMILES[H][C@]1(OC(=O)C2=C1C=CC1=C2OCO1)[C@@]1([H])N(C)CCC2=CC3=C(OCO3)C=C12

Targets

Q92952KCNN1Q9H2S1KCNN2A9X444Muscle nicotinic acetylcholine receptor

What you can answer from here — as of July 07, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Bicuculline, and which of those have an active Phase 3 trial?

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