Neon

Identification

Summary

Neon is a diagnostic tracer gas used in pulmonary function tests.

Generic Name
Neon
DrugBank Accession Number
DB11589
Background

Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a reddish-orange light, and is commonly used in low-voltage neon glow lamps, high-voltage discharge tubes, and signs with fluorescent lighting. It is also used in vacuum tubes, high-voltage indicators, lightning arresters, wave meter tubes, television tubes, and helium–neon lasers. Neon may be used in the clinical setting as a diagnostic tracer gas in a gas analyzer for a lung diffusion test. Other clinical applications of neon, such as a radiotherapy in various cancers 1, have been studied.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 20.1797
Monoisotopic: 19.99244018
Chemical Formula
Ne
Synonyms
  • Ne
  • neón
  • néon
  • Neon

Pharmacology

Indication

Indicated for use as a diagnostic tracer gas in pulmonary function tests.

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

A study demonstrated that neon beam radiotherapy improved the 5-year actuarial disease-specific survival rate and local control in patients with paranasal sinus tumours, macroscopic salivary gland tumours, bile duct carcinomas, macroscopic soft tissue and bone sarcomas, and advanced prostate carcinomas 1.

Mechanism of action

In a pulmonary diffusion capacity test, the diffusing capacity for carbon monoxide (Dlco) assesses the rate at which oxygen is transferred from the lung to the pulmonary capillary bed. In a neon gas analyzer, the mixture of carbon monoxide, neon gas, oxygen, and the balance nitrogen is inhaled by the individual and is eventually exhaled after being held at near full inspiration for brief seconds. The concentrations and ratio of carbon monoxide and neon is measured in the alveolar fraction of the expired gas. The change in the concentration of the tracer gas reflects the mean alveolar carbon monoxide concentration at the start of the breath hold and provides a measure of alveolar volume by gas dilution 2.

Neon ion radiotherapy has high linear energy transfer thus produces biological behaviour similar to neutron beams 1. The rays are associated with a reduction in the oxygen enhancement ratio, which allows for more specificity for hypoxic cells, less variation in cell-cycle related radio sensitivity, and less capability for repair of radiation injury 1.

Absorption

No pharmacokinetic data available.

Volume of distribution

No pharmacokinetic data available.

Protein binding

No pharmacokinetic data available.

Metabolism

No pharmacokinetic data available.

Route of elimination

No pharmacokinetic data available.

Half-life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Adverse Effects
Medicalerrors
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Toxicity

In high concentrations, neon gas may act as a simple asphyxiant by displacing oxygen from the atmosphere leading to decreased alveolar partial oxygen pressure and hypoxemia 3.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Co-NE-O2-N2 MixtureNeon (0.5 % v/v) + Carbon monoxide (0.3 % v/v) + Nitrogen (78.2 % v/v) + Oxygen (21 % v/v)GasRespiratory (inhalation)Messer Canada Inc.1995-12-31Not applicableCanada flag
Lung Diffusion Test Mix No Ne CoNeon (0.5 %) + Carbon monoxide (0.3 %) + Nitrogen (78.2 %) + Oxygen (21 %)GasRespiratory (inhalation)Praxair, Inc.1968-12-31Not applicableCanada flag
Lung Diffusion Test MixtureNeon (1 %) + Acetylene (.6 %) + Carbon monoxide (1.5 %) + Nitrogen (81.7 %) + Oxygen (23 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1982-12-311997-12-24Canada flag
Lung Diffusion Test MixtureNeon (.5 %) + Acetylene (.5 %) + Carbon dioxide (.4 %) + Medical air (98.6 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1961-12-311997-12-24Canada flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous noble gases
Sub Class
Not Available
Direct Parent
Homogeneous noble gases
Alternative Parents
Not Available
Substituents
Homogeneous noble gas
Molecular Framework
Not Available
External Descriptors
monoatomic neon (CHEBI:49993)
Affected organisms
Not Available

Chemical Identifiers

UNII
4VB4Y46AHD
CAS number
7440-01-9
InChI Key
GKAOGPIIYCISHV-UHFFFAOYSA-N
InChI
InChI=1S/Ne
IUPAC Name
neon
SMILES
[Ne]

References

General References
  1. Linstadt DE, Castro JR, Phillips TL: Neon ion radiotherapy: results of the phase I/II clinical trial. Int J Radiat Oncol Biol Phys. 1991 Apr;20(4):761-9. [Article]
  2. Castile RG, Davis SD (2012). 12. In Kendig & Chernick's Disorders of the Respiratory Tract in Children (8th ed., pp. 211). Elsevier Saunders. [ISBN:978-1-4377-1984-0]
  3. Neon, Elemental - National Library of Medicine HSDB Database - Toxnet [Link]
  4. FDA Code of Federal Regulations (CFR) Title 21 Sec. 868.1670 Neon gas analyzer [Link]
PubChem Compound
23935
PubChem Substance
347827996
ChemSpider
22377
RxNav
7301
ChEBI
33310
Wikipedia
Neon
MSDS
Download (145 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Unknown StatusDiagnosticVasoplegia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GasRespiratory (inhalation)
Prices
Not Available
Patents
Not Available

Properties

State
Gas
Experimental Properties
PropertyValueSource
melting point (°C)-248.7MSDS
boiling point (°C)-246.1MSDS
water solubilityNegligibleMSDS
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on April 28, 2016 19:07 / Updated on June 12, 2020 16:53