Dutogliptin

DB11723InvestigationalSmall molecule

Dutogliptin has been investigated for the treatment of Diabetes Mellitus, Type II.

Mechanism: Dutogliptin is a potent and selective inhibitor of DPP4, a serine protease that has emerged as an important target for the treatment of type 2 diabetes. Inhibiting DPP4 increases the physiological levels of regulatory peptides, such as GLP-1, an important modulator of insulin response and digestion.
Curator reviewed
Formula / weight: C₁₀H₂₀BN₃O₃ · 241.1 g/mol (avg)
Code names: PHX1149

Resolves to

Compound

Structure

InChIKeyDVJAMEIQRSHVKC-BDAKNGLRSA-NSMILESOB(O)[C@@H]1CCCN1C(=O)CN[C@@H]1CCNC1

Targets

What you can answer from here — as of August 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

656Drug interactionsStructured to mechanism, not free text

7Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Dutogliptin, and which of those have an active Phase 3 trial?

Create a free account or log in to explore the full data card.