PF-04991532

DB11765InvestigationalSmall molecule

PF-04991532 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Glucose Metabolism Disorders.

Mechanism: Pharmacologically active on Hexokinase-4
Curator reviewed
Formula / weight: C₁₈H₁₉F₃N₄O₃ · 396.3637 g/mol (avg)
Code names: PF-04991532

Resolves to

Compound

UNIIAJ212MS2O2CAS1215197-37-7ChEMBLCHEMBL2165620PubChem46181428

Structure

InChIKeyGKMLFBRLRVQVJO-ZDUSSCGKSA-NSMILESOC(=O)C1=CC=C(NC(=O)[C@H](CC2CCCC2)N2C=NC(=C2)C(F)(F)F)N=C1

Targets

P35557GCK

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with PF-04991532, and which of those have an active Phase 3 trial?

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