Lomibuvir

DB11954InvestigationalSmall molecule

Lomibuvir has been used in trials studying the treatment of Chronic Hepatitis C Virus and Chronic Hepatitis C Virus Infection.

Mechanism: Pharmacologically active on RNA-directed RNA polymerase
Curator reviewed
Formula / weight: C₂₅H₃₅NO₄S · 445.62 g/mol (avg)
Code names: VX-222

Resolves to

Compound

Structure

InChIKeyWPMJNLCLKAKMLA-VVPTUSLJSA-NSMILESC[C@H]1CC[C@@H](CC1)C(=O)N([C@H]1CC[C@H](O)CC1)C1=C(SC(=C1)C#CC(C)(C)C)C(O)=O

Targets

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Lomibuvir, and which of those have an active Phase 3 trial?

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