GW-406381

DB12009InvestigationalSmall molecule

GW-406381 has been used in trials studying the treatment of Pain, Trauma, Neurodynia, Dental Pain, and Hyperalgesia, among others.

Mechanism: Pharmacologically active on Prostaglandin G/H synthase 2
Curator reviewed
Formula / weight: C₂₁H₁₉N₃O₃S · 393.46 g/mol (avg)
Code names: GW-406381

Resolves to

Compound

Structure

InChIKeyNXMZBNYLCVTRGB-UHFFFAOYSA-NSMILESCCOC1=CC=C(C=C1)C1=NN2N=CC=CC2=C1C1=CC=C(C=C1)S(C)(=O)=O

Targets

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with GW-406381, and which of those have an active Phase 3 trial?

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