Crenigacestat

DB12050InvestigationalSmall molecule

Crenigacestat has been used in trials studying the treatment and basic science of LYMPHOMA, Neoplasms, Solid Tumor, COLON CANCER, and BREAST CANCER, among others.

Chemical structure of Crenigacestat
Formula / weight
C22H23F3N4O4 · 464.445 g/mol (avg)
Code names
BMS-986405 · JSMD194 · LY-3039478

Resolves to

Compound
UNII923X28214SCAS1421438-81-4ChEMBLCHEMBL2338397PubChem71236992
Structure
InChIKeyYCBAQKQAINQRFW-UGSOOPFHSA-NSMILESC[C@H](NC(=O)CCC(F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CN=C2N(CCO)C1=O
Targets
P46531NOTCH1Q99466NOTCH4

What you can answer from here — as of September 16, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
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9Clinical trialsPhase, status and sponsor resolved per trial
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Crenigacestat, and which of those have an active Phase 3 trial?

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