Polihexanide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Polihexanide
DrugBank Accession Number
DB12277
Background

Polihexanide has been used in trials studying the treatment, prevention, and supportive care of Caries, Neoplasm, Skin Diseases, Nail Diseases, and Dental Plaque, among others.

Type
Small Molecule
Groups
Approved, Investigational
Synonyms
  • Polihexanide
  • Polyhexamethylene biguanide

Pharmacology

Indication

Not Available

Pharmacology
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Polihexanide hydrochloride4XI611249632289-58-0Not applicable
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Disinfecting Wet WipeCloth0.9 mg/1TopicalFive Hertz (Xiamen) Medical Supplies Co., Ltd.2020-03-30Not applicableUS flag
Disposable DisinfectantSpray0.4 g/100mLTopicalHunan Cihui Medical Technology Co., Ltd.2020-04-15Not applicableUS flag
Disposable Hand Antibacterial GelGel0.4 g/100mLTopicalBiocaro Pharmaceutical Co., Ltd2020-03-30Not applicableUS flag
HBA Anti bacterial LiquidSpray0.2 g/100mLTopicalHenan Huibo Medical Co., Ltd.2020-07-22Not applicableUS flag
HBA Sanitary WipesSolution5.44 mg/1TopicalHenan Huibo Medical Co., Ltd.2020-07-22Not applicableUS flag
LeYiJie Alcohol Hand Wash Antibacterial GelGel0.4 g/100mLTopicalBiocaro Pharmaceutical Co., Ltd2020-03-30Not applicableUS flag
PHMB DisinfectantSpray3.5 g/500mLExtracorporealUgel Pharm Tech (Shanghai) Co., Ltd.2020-05-22Not applicableUS flag
PHMB DisinfectantSpray0.39 mg/1mLTopicalFive Hertz (Xiamen) Medical Supplies Co., Ltd.2020-03-30Not applicableUS flag
Wash free hand sanitizer(Alcohol free)Solution1 mg/1mLTopicalShanghai Quanli Daily Necessities Co., Ltd.2020-03-30Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
(Aenc) Disinfectant WATER-FREE HAND FOAMPolihexanide (0.56 mg/100mL) + Didecyldimethylammonium chloride (0.11 mg/100mL)SolutionTopicalYantai Dongke Lvzhiyuan Disinfection Pharmaceutical Co., Ltd.2020-05-20Not applicableUS flag
Cleansing Disinfection WipesPolihexanide (0.05 1/1001) + Benzalkonium chloride (0.1 1/1001) + Didecyldimethylammonium chloride (0.3 1/1001) + Ethanol (10 1/1001)ClothTopicalGuangdong Bolicen Bio-Technology Co., Ltd.2020-07-12Not applicableUS flag
COMPLETE MULTI-PURPOSE SOLUTIONPolihexanide (0.0001 G/100ML) + Poloxamer 237 (0.05 G/100ML)SolutionOphthalmicบริษัท อลิซไลฟ์ จำกัด จำกัด2016-12-062019-10-21Thailand flag
Ucheer CPolihexanide hydrochloride (0.3 g/100mL) + Benzalkonium chloride (0.3 g/100mL)LiquidTopicalUcheer Purification and Pollution-control Technology(Zhejiang)Co.,Ltd.2020-04-15Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
(Aenc) Disinfectant WATER-FREE HAND FOAMPolihexanide (0.56 mg/100mL) + Didecyldimethylammonium chloride (0.11 mg/100mL)SolutionTopicalYantai Dongke Lvzhiyuan Disinfection Pharmaceutical Co., Ltd.2020-05-20Not applicableUS flag
Disinfecting Wet WipePolihexanide (0.9 mg/1)ClothTopicalFive Hertz (Xiamen) Medical Supplies Co., Ltd.2020-03-30Not applicableUS flag
Disposable DisinfectantPolihexanide (0.4 g/100mL)SprayTopicalHunan Cihui Medical Technology Co., Ltd.2020-04-15Not applicableUS flag
Disposable Hand Antibacterial GelPolihexanide (0.4 g/100mL)GelTopicalBiocaro Pharmaceutical Co., Ltd2020-03-30Not applicableUS flag
HBA Anti bacterial LiquidPolihexanide (0.2 g/100mL)SprayTopicalHenan Huibo Medical Co., Ltd.2020-07-22Not applicableUS flag
HBA Sanitary WipesPolihexanide (5.44 mg/1)SolutionTopicalHenan Huibo Medical Co., Ltd.2020-07-22Not applicableUS flag
LeYiJie Alcohol Hand Wash Antibacterial GelPolihexanide (0.4 g/100mL)GelTopicalBiocaro Pharmaceutical Co., Ltd2020-03-30Not applicableUS flag
PHMB DisinfectantPolihexanide hydrochloride (3.5 g/500mL)SprayExtracorporealUgel Pharm Tech (Shanghai) Co., Ltd.2020-05-22Not applicableUS flag
PHMB DisinfectantPolihexanide (0.39 mg/1mL)SprayTopicalFive Hertz (Xiamen) Medical Supplies Co., Ltd.2020-03-30Not applicableUS flag
Wash free hand sanitizer(Alcohol free)Polihexanide (1 mg/1mL)SolutionTopicalShanghai Quanli Daily Necessities Co., Ltd.2020-03-30Not applicableUS flag

Categories

ATC Codes
D08AC05 — Polihexanide
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
322U039GMF
CAS number
28757-47-3

References

General References
  1. DailyMed: HBA Antibacterial Liquid (polihexanide) topical spray [Link]
PubChem Substance
347911310
RxNav
1373041
Wikipedia
Polyhexanide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionNail Diseases / Nails, Ingrown / Skin Diseases1
3Active Not RecruitingTreatmentAcanthamoeba Keratitis1
3CompletedSupportive CareNeoplasms / Wounds and Injuries1
3CompletedTreatmentSurgical Site Infections1
2RecruitingTreatmentDistal Subungual Onychomycosis / Fungus, Nail / Infections, Fungal1
1CompletedTreatmentAcanthamoeba Keratitis1
Not AvailableCompletedPreventionCaries / Oral Surgical Wound Infection / Periimplantitis / Periodontal Diseases / Plaque, Dental1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionTopical
ClothTopical
SolutionOphthalmic
ClothTopical0.9 mg/1
SprayTopical0.4 g/100mL
SprayTopical0.2 g/100mL
SolutionTopical5.44 mg/1
GelTopical0.4 g/100mL
ShampooTopical0.8 g
SprayExtracorporeal3.5 g/500mL
SprayTopical0.39 mg/1mL
LiquidTopical
SolutionTopical1 mg/1mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on October 20, 2016 21:48 / Updated on February 21, 2021 18:53