10-hydroxycamptothecin

DB12385ExperimentalSmall molecule

10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)).

Chemical structure of 10-hydroxycamptothecin
Formula / weight
C20H16N2O5 · 364.357 g/mol (avg)
Code names
NSC-107124

Resolves to

Compound
UNII9Z01632KRVCAS19685-09-7ChEMBLCHEMBL273862ChEBI81395PubChem97226KEGGC17939
Structure
InChIKeyHAWSQZCWOQZXHI-FQEVSTJZSA-NSMILESCC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=C1N=C1C=CC(O)=CC1=C3)C2=O
Targets
P11387TOP1

What you can answer from here — as of March 06, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
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39Drug interactionsStructured to mechanism, not free text
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with 10-hydroxycamptothecin, and which of those have an active Phase 3 trial?

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