Sagopilone

DB12391InvestigationalSmall molecule

Sagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is... It is a so-called fully synthetic epothilone and is the first such compound to be in clinical development to combat several forms of cancer.

Mechanism: Epothilones are a new class of cytotoxic agents that induce tubulin polymerization. Sagopilone, the only fully synthetic, third-generation analogue of epothilone B, is a highly potent tubulin stabilizer that has shown substantial preclinical antitumor activity, including against taxane-resistant models.
Curator reviewed
Formula / weight: C₃₀H₄₁NO₆S · 543.72 g/mol (avg)
Code names: BAY86-5302 · DE-03757 · ZK-219477 · ZK-EPO

Resolves to

Compound

UNIIKY72JU32FOCAS305841-29-6ChEMBLCHEMBL2304041PubChem11284169

Structure

InChIKeyBFZKMNSQCNVFGM-UCEYFQQTSA-NSMILESC[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](CC=C)[C@H]1O)C1=CC=C2SC(C)=NC2=C1

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

323Drug interactionsStructured to mechanism, not free text

13Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which companies are running trials of Sagopilone, in which indications and phases, and which of those programs are still active?

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