9-aminocamptothecin

DB12515InvestigationalSmall molecule

Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal Cancer, and Ovarian Neoplasms, among others.

Mechanism: Pharmacologically active on DNA topoisomerase 1
Curator reviewed
Formula / weight: C₂₀H₁₇N₃O₄ · 363.373 g/mol (avg)
Also known as: Aminocamptothecin
Code names: NSC-603071

Resolves to

Compound

UNII5MB77ICE2QCAS91421-43-1ChEMBLCHEMBL274070ChEBI80755PubChem72402KEGGC16822

Structure

InChIKeyFUXVKZWTXQUGMW-FQEVSTJZSA-NSMILESCC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=C1N=C1C=CC=C(N)C1=C3)C2=O

Targets

P11387TOP1

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

528Drug interactionsStructured to mechanism, not free text

9Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with 9-aminocamptothecin, and which of those have an active Phase 3 trial?

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