Lotamilast

DB12776InvestigationalSmall molecule

E6005 has been used in trials studying the treatment of Atopic Dermatitis.

Chemical structure of Lotamilast
Mechanism
Curator reviewed
Formula / weight
C26H24N4O5 · 472.501 g/mol (avg)
Code names
E6005

Resolves to

Compound
UNIITO043KKB9CCAS947620-48-6ChEMBLCHEMBL3989967PubChem24864553
Structure
InChIKeyBBTFKAOFCSOZMB-UHFFFAOYSA-NSMILESCNC1=NC(C2=CC=CC(NC(=O)C3=CC=C(C=C3)C(=O)OC)=C2)=C2C=C(OC)C(OC)=CC2=N1

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1Drug interactionStructured to mechanism, not free text
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2Clinical trialsPhase, status and sponsor resolved per trial
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3+ReferencesStructured and connected to the statements they support
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Which companies are running trials of Lotamilast, in which indications and phases, and which of those programs are still active?

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