Rivipansel
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Rivipansel
- DrugBank Accession Number
- DB12778
- Background
Rivipansel has been used in trials studying the other, basic science, and treatment of Pain Crisis, Renal impairment, Anemia, Sickle Cell, Sickle Cell Disease, and Sickle Cell Disorders, among others.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 1447.42
Monoisotopic: 1446.356063149 - Chemical Formula
- C58H74N6O31S3
- Synonyms
- GMI-1070
- External IDs
- PF-06460031
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Rivipansel sodium 11AEN6VWDN 1189037-60-2 QQDCIMVGFXSAJH-DJFGCAFRSA-J
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4B115V09LB
- CAS number
- 927881-99-0
- InChI Key
- VXBNTHRZPJLRSS-PTCSXESPSA-N
- InChI
- InChI=1S/C58H74N6O31S3/c1-27-45(69)47(71)48(72)56(90-27)95-49-35(62-53(74)36-23-41(66)64-58(78)63-36)19-31(20-37(49)92-57-51(94-55(77)29-10-6-3-7-11-29)50(46(70)39(24-65)93-57)91-38(54(75)76)16-28-8-4-2-5-9-28)52(73)60-13-12-59-42(67)25-88-14-15-89-26-43(68)61-34-21-32(96(79,80)81)17-30-18-33(97(82,83)84)22-40(44(30)34)98(85,86)87/h3,6-7,10-11,17-18,21-23,27-28,31,35,37-39,45-51,56-57,65,69-72H,2,4-5,8-9,12-16,19-20,24-26H2,1H3,(H,59,67)(H,60,73)(H,61,68)(H,62,74)(H,75,76)(H,79,80,81)(H,82,83,84)(H,85,86,87)(H2,63,64,66,78)/t27-,31+,35-,37+,38-,39+,45+,46-,47+,48-,49+,50-,51+,56-,57+/m0/s1
- IUPAC Name
- (2S)-2-{[(2R,3R,4S,5S,6R)-3-(benzoyloxy)-2-{[(1R,2R,3S,5R)-3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-amido)-2-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-5-({2-[2-(2-{[(3,6,8-trisulfonaphthalen-1-yl)carbamoyl]methoxy}ethoxy)acetamido]ethyl}carbamoyl)cyclohexyl]oxy}-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-3-cyclohexylpropanoic acid
- SMILES
- [H][C@@](CC1CCCCC1)(O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](O[C@@H]2C[C@@H](C[C@H](NC(=O)C3=CC(=O)NC(=O)N3)[C@H]2O[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)C(=O)NCCNC(=O)COCCOCC(=O)NC2=C3C(=CC(=C2)S(O)(=O)=O)C=C(C=C3S(O)(=O)=O)S(O)(=O)=O)[C@@H]1OC(=O)C1=CC=CC=C1)C(O)=O
References
- General References
- Not Available
- External Links
- PubChem Substance
- 347911379
- ChemSpider
- 30790724
- ChEMBL
- CHEMBL3707446
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Sickle Cell Anemia 1 3 Terminated Treatment Pain Crisis / Sickle Cell Anemia / Sickle Cell Disease (SCD) / Vaso-occlusive Crisis 1 2 Completed Treatment Pain Crisis / Sickle Cell Disease (SCD) / Vaso-occlusive Crisis 1 1 Completed Basic Science Healthy Subjects (HS) 1 1 Completed Other Healthy Subjects (HS) 2 1 Completed Other Healthy Subjects (HS) / Impaired Renal Function 1 1 Completed Other Moderate Hepatic Impairment / Normal Hepatic Function 1 1, 2 Completed Treatment Sickle Cell Disease (SCD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 3.09 mg/mL ALOGPS logP -1 ALOGPS logP -8.8 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) -3.1 Chemaxon pKa (Strongest Basic) -3.9 Chemaxon Physiological Charge -4 Chemaxon Hydrogen Acceptor Count 30 Chemaxon Hydrogen Donor Count 15 Chemaxon Polar Surface Area 567.07 Å2 Chemaxon Rotatable Bond Count 30 Chemaxon Refractivity 328.37 m3·mol-1 Chemaxon Polarizability 140.15 Å3 Chemaxon Number of Rings 8 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at October 21, 2016 00:11 / Updated at April 28, 2023 11:47