Radium Ra-223

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Radium Ra-223
DrugBank Accession Number
DB12813
Background

Radium 223 is under investigation in clinical trial NCT02463799 (Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 223.0185
Monoisotopic: 223.01849714
Chemical Formula
Ra
Synonyms
  • Radium-223

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as homogeneous alkaline earth metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkaline earth metal atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous metal compounds
Class
Homogeneous alkaline earth metal compounds
Sub Class
Not Available
Direct Parent
Homogeneous alkaline earth metal compounds
Alternative Parents
Not Available
Substituents
Homogeneous alkaline earth metal
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
8BR2SOL3L1
CAS number
15623-45-7
InChI Key
HCWPIIXVSYCSAN-OIOBTWANSA-N
InChI
InChI=1S/Ra/i1-3
IUPAC Name
(223Ra)radium
SMILES
[223Ra]

References

General References
Not Available
PubChem Compound
6335825
PubChem Substance
347828986
ChemSpider
4891413

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingTreatmentRefractory, metastatic hormone-refractory Prostate cancer1
3Active Not RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer (CRPC)1
3RecruitingTreatmentProstate Cancer1
2Active Not RecruitingSupportive CarePain / Refractory, metastatic hormone-refractory Prostate cancer1
2Active Not RecruitingTreatmentProstate Cancer2
2CompletedBasic ScienceProstate Cancer1
2CompletedTreatmentProstate Cancer2
2Not Yet RecruitingTreatmentAdenocarcinoma, Prostate / Castration-Resistant / Metastatic Prostate Adenocarcinoma1
2RecruitingTreatmentBiochemical Recurrent Prostate Cancer1
2RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer (CRPC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on October 21, 2016 00:26 / Updated on June 12, 2020 16:53