TNP-470

DB08633InvestigationalSmall molecule

O-(chloroacetylcarbamoyl)fumagillol (TNP-470) has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, and Pancreatic Neoplasms.

Chemical structure of TNP-470
Mechanism
Curator reviewed
Formula / weight
C19H28ClNO6 · 401.882 g/mol (avg)
Also known as
O-chloroacetylcarbamoylfumagillol
Code names
AGM-1470 · DRG-0148 · NSC-642492 · TNP-470

Resolves to

Compound
UNIIX47GR46481CAS129298-91-5ChEMBLCHEMBL424278ChEBI90748PubChem369976
Structure
InChIKeyMSHZHSPISPJWHW-PVDLLORBSA-NSMILES[H][C@]1(CC=C(C)C)O[C@]1(C)[C@@]1([H])[C@]([H])(OC)[C@@]([H])(CC[C@]11CO1)OC(=O)NC(=O)CCl
Targets
P50579METAP2

What you can answer from here — as of August 26, 2024

1Protein targetEach mapped to UniProt, with action and pharmacological action
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48Drug interactionsStructured to mechanism, not free text
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2Clinical trialsPhase, status and sponsor resolved per trial
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with TNP-470, and which of those have an active Phase 3 trial?

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