Pyronaridine
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Pyronaridine
- Accession Number
- DB12975
- Description
Pyronaridine has been investigated for the treatment of Malaria.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Pyronaridine (DB12975)
- Weight
- Average: 518.06
Monoisotopic: 517.224453 - Chemical Formula
- C29H32ClN5O2
- Synonyms
- Not Available
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAcetophenazine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Acetophenazine. Alimemazine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Alimemazine. Artemether The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Artemether. Butaperazine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Butaperazine. Chlorpromazine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Chlorpromazine. Dapsone The risk or severity of adverse effects can be increased when Pyronaridine is combined with Dapsone. Fluphenazine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Fluphenazine. Lumefantrine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Lumefantrine. Mesoridazine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Mesoridazine. Methotrimeprazine The risk or severity of QTc prolongation can be increased when Pyronaridine is combined with Methotrimeprazine. Additional Data Available- Extended DescriptionExtended DescriptionAvailable for Purchase
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - SeveritySeverityAvailable for Purchase
A severity rating for each drug interaction, from minor to major.
Learn more - Evidence LevelEvidence LevelAvailable for Purchase
A rating for the strength of the evidence supporting each drug interaction.
Learn more - ActionActionAvailable for Purchase
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- Not Available
Products
- Product Ingredients
Ingredient UNII CAS InChI Key Pyronaridine tetraphosphate 2T289F9ACO Not Available YKUQEKXHQFYULM-UHFFFAOYSA-N
Categories
- ATC Codes
- P01BF06 — Artesunate and pyronaridine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 4-aminoquinolines. These are organic compounds containing an amino group attached to the 4-position of a quinoline ring system.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Quinolines and derivatives
- Sub Class
- Aminoquinolines and derivatives
- Direct Parent
- 4-aminoquinolines
- Alternative Parents
- Chloroquinolines / Naphthyridines / p-Aminophenols / Aniline and substituted anilines / Phenylmethylamines / Benzylamines / Alkyl aryl ethers / Aminopyridines and derivatives / Aralkylamines / Primary aromatic amines show 8 more
- Substituents
- 4-aminoquinoline / Alkyl aryl ether / Amine / Aminophenol / Aminopyridine / Aniline or substituted anilines / Aralkylamine / Aromatic heteropolycyclic compound / Aryl chloride / Aryl halide show 26 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
Chemical Identifiers
- UNII
- TD3P7Q3SG6
- CAS number
- 74847-35-1
- InChI Key
- DJUFPMUQJKWIJB-UHFFFAOYSA-N
- InChI
- InChI=1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32)
- IUPAC Name
- 4-({7-chloro-2-methoxybenzo[b]1,5-naphthyridin-10-yl}amino)-2,6-bis[(pyrrolidin-1-yl)methyl]phenol
- SMILES
- COC1=NC2=C(NC3=CC(CN4CCCC4)=C(O)C(CN4CCCC4)=C3)C3=CC=C(Cl)C=C3N=C2C=C1
References
- General References
- Not Available
- External Links
- PubChem Compound
- 5485198
- PubChem Substance
- 347829115
- ChemSpider
- 10647812
- BindingDB
- 53353
- ChEBI
- 135951
- ChEMBL
- CHEMBL35228
- ZINC
- ZINC000003882897
- Wikipedia
- Pyronaridine
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Malaria caused by Plasmodium falciparum 1 4 Recruiting Treatment Plasmodium Falciparum Malaria (Drug Resistant) 1 3 Completed Treatment Plasmodium Infections 5 3 Not Yet Recruiting Treatment Coronavirus Disease 2019 (COVID‑19) / Plasmodium Infections 1 3 Terminated Treatment Plasmodium Infections 1 2 Active Not Recruiting Treatment Malaria caused by Plasmodium falciparum 1 2 Completed Treatment Malaria caused by Plasmodium falciparum 1 2 Completed Treatment Plasmodium Falciparum Malaria 1 2 Completed Treatment Schistosomiasis haematobia 1 2 Completed Treatment Uncomplicated Plasmodium Falciparum Malaria 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0132 mg/mL ALOGPS logP 5.78 ALOGPS logP 4.22 ChemAxon logS -4.6 ALOGPS pKa (Strongest Acidic) 7.96 ChemAxon pKa (Strongest Basic) 10.08 ChemAxon Physiological Charge 2 ChemAxon Hydrogen Acceptor Count 7 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 73.75 Å2 ChemAxon Rotatable Bond Count 7 ChemAxon Refractivity 147.74 m3·mol-1 ChemAxon Polarizability 57.85 Å3 ChemAxon Number of Rings 6 ChemAxon Bioavailability 1 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created on October 20, 2016 19:44 / Updated on November 27, 2020 12:20