Nepicastat

DB12979InvestigationalSmall molecule

Nepicastat has been investigated for the treatment of Cocaine Dependence and Posttraumatic Stress Disorder.

Mechanism: Pharmacologically active on Dopamine beta-hydroxylase
Curator reviewed
Formula / weight: C₁₄H₁₅F₂N₃S · 295.35 g/mol (avg)
Code names: RS-25560-197 · SYN-117

Resolves to

Compound

Structure

InChIKeyYZZVIKDAOTXDEB-JTQLQIEISA-NSMILESNCC1=CNC(=S)N1[C@H]1CCC2=C(C1)C=C(F)C=C2F

Targets

Transporters

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2TransportersSubstrate / inhibitor direction, not just membership

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nepicastat, and which of those have an active Phase 3 trial?

Create a free account or log in to explore the full data card.