This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Summary
Biapenem is a carbapenem antibiotic indicated in the treatment of bacterial infections.
- Generic Name
- Biapenem
- DrugBank Accession Number
- DB13028
- Background
Biapenem has been used in trials studying the treatment of Bacterial Infections.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Biapenem (DB13028)
- Weight
- Average: 350.39
Monoisotopic: 350.10487625 - Chemical Formula
- C15H18N4O4S
- Synonyms
- Biapenem
- External IDs
- CL 186,815
- CL-186815
- L-627
- LJ C10,627
- LJC-10627
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Bacterial pyelonephritis •••••••••••• •••••••••• ••••••• ••• •••••••• Treatment of Bloodstream infections caused by susceptible bacteria •••••••••••• •••••••••• ••••••• ••• •••••••• Treatment of Endometritis bacterial •••••••••••• •••••••••• ••••••• ••• •••••••• Treatment of Lung abscess •••••••••••• •••••••••• ••••••• ••• •••••••• Treatment of Peritonitis bacterial •••••••••••• •••••••••• ••••••• ••• •••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcenocoumarol The risk or severity of bleeding can be increased when Biapenem is combined with Acenocoumarol. Ambroxol The risk or severity of methemoglobinemia can be increased when Biapenem is combined with Ambroxol. Articaine The risk or severity of methemoglobinemia can be increased when Biapenem is combined with Articaine. BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Biapenem. Benzocaine The risk or severity of methemoglobinemia can be increased when Biapenem is combined with Benzocaine. - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
Categories
- ATC Codes
- J01DH05 — Biapenem
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as thienamycins. These are beta-lactam antibiotics that differ from penicillins in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Lactams
- Sub Class
- Beta lactams
- Direct Parent
- Thienamycins
- Alternative Parents
- Alpha amino acids and derivatives / Pyrroline carboxylic acids / Azepines / Vinylogous thioesters / Triazoles / Tertiary carboxylic acid amides / Heteroaromatic compounds / Thioenol ethers / Azetidines / Carboxylic acid salts show 12 more
- Substituents
- 1,2,4-triazole / Alcohol / Alpha-amino acid or derivatives / Aromatic heteropolycyclic compound / Azacycle / Azepine / Azetidine / Azole / Carbonyl group / Carboxamide group show 24 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- organic sulfide, carbapenems, pyrazolotriazole (CHEBI:3089)
- Affected organisms
- Pseudomonas aeruginosa
- Streptococcus pneumoniae
- Haemophilus influenzae
- Escherichia coli
- Enterococcus faecalis
- Moraxella catarrhalis
- Enterococcus hirae
- Acinetobacter spp.
- Enterobacter spp.
- Klebsiella spp.
- Citrobacter spp.
- Proteus spp.
- Peptostreptococcus spp.
- Bacteroides spp.
- Fusobacterium spp.
- Serratia spp.
- Staphylococcus
- Streptococcus
Chemical Identifiers
- UNII
- YR5U3L9ZH1
- CAS number
- 120410-24-4
- InChI Key
- MRMBZHPJVKCOMA-YJFSRANCSA-N
- InChI
- InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/m1/s1
- IUPAC Name
- 6-{[(4R,5S,6S)-2-carboxylato-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl}-5H,6H,7H-4λ⁵-pyrazolo[1,2-a][1,2,4]triazol-4-ylium
- SMILES
- [H][C@](C)(O)[C@@]1([H])C(=O)N2C(C([O-])=O)=C(SC3CN4C=NC=[N+]4C3)[C@]([H])(C)[C@]12[H]
References
- General References
- FDA Thailand Product Information: Omegacin (biapenem) for intravenous infusion [Link]
- External Links
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data1 Completed Treatment Bacterial Infections / Healthy Volunteers (HV) 2 somestatus stop reason just information to hide Not Available Recruiting Not Available Elderly Infection 1 somestatus stop reason just information to hide Not Available Unknown Status Not Available High-dose Biapenem 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Powder 300 mg/1vial - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 2.75 mg/mL ALOGPS logP -2 ALOGPS logP -6.1 Chemaxon logS -2.2 ALOGPS pKa (Strongest Acidic) 3.51 Chemaxon pKa (Strongest Basic) -1.6 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 102.37 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 120.82 m3·mol-1 Chemaxon Polarizability 35.06 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 190.0346138 predictedDarkChem Lite v0.1.0 [M-H]- 163.11008 predictedDeepCCS 1.0 (2019) [M+H]+ 190.5598138 predictedDarkChem Lite v0.1.0 [M+H]+ 165.50565 predictedDeepCCS 1.0 (2019) [M+Na]+ 189.8393138 predictedDarkChem Lite v0.1.0 [M+Na]+ 171.28456 predictedDeepCCS 1.0 (2019)
Drug created at October 21, 2016 02:10 / Updated at June 12, 2021 10:54