PAC-1

DB13048InvestigationalSmall molecule

PAC-1 has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.

Chemical structure of PAC-1
Mechanism
Curator reviewed
Formula / weight
C23H28N4O2 · 392.503 g/mol (avg)
Also known as
Procaspase activating compound 1 · Procaspase-activating compound 1

Resolves to

Compound
UNII9LIS8N0B2CCAS315183-21-2ChEMBLCHEMBL591429PubChem6851947
Structure
InChIKeyYQNRVGJCPCNMKT-LFVJCYFKSA-NSMILESOC1=C(\C=N\NC(=O)CN2CCN(CC3=CC=CC=C3)CC2)C=CC=C1CC=C
Targets
P42574CASP3

What you can answer from here — as of April 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
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4Clinical trialsPhase, status and sponsor resolved per trial
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3+ReferencesStructured and connected to the statements they support
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Which drugs share a target with PAC-1, and which of those have an active Phase 3 trial?

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