This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Lobaplatin
- DrugBank Accession Number
- DB13049
- Background
Lobaplatin has been used in trials studying the treatment of Breast Cancer, Hepatocellular Carcinoma, and Lobaplatin and Gemcitabine in Combination, Second-line Treatments on Advanced Osteosarcoma.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Lobaplatin (DB13049)
- Weight
- Average: 397.338
Monoisotopic: 397.096534 - Chemical Formula
- C9H18N2O3Pt
- Synonyms
- Lobaplatin
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- OX5XK1JD8C
- CAS number
- 135558-11-1
- InChI Key
- RLXPIABKJFUYFG-DOYDWZMXSA-M
- InChI
- InChI=1S/C6H14N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-6H,1-4,7-8H2;2H,1H3,(H,5,6);/q;-1;+2/p-1/t5-,6-;2-;/m00./s1
- IUPAC Name
- platinum(2+) 1-[(1R,2R)-2-(aminomethyl)cyclobutyl]methanamine (2S)-2-oxidopropanoate
- SMILES
- [Pt++].C[C@H]([O-])C([O-])=O.NC[C@@H]1CC[C@H]1CN
References
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Esophageal Cancer 1 3 Recruiting Treatment Liver, Cancer of, Primary Resectable 1 3 Unknown Status Treatment Esophageal Carcinoma 1 3 Unknown Status Treatment Hepatocellular Carcinoma 1 2 Not Yet Recruiting Treatment Chemotherapy Effects / Colorectal Cancer / Metastatic Cancer / Surgery / Survival 1 2 Recruiting Treatment Chemotherapy Effects / Gastric Cancer / Metastatic Cancer / Surgery / Survival 1 2 Recruiting Treatment Triple-Negative Breast Cancer 1 2 Unknown Status Treatment Breast Cancer 1 2 Unknown Status Treatment Locally advanced Squamous cell carcinoma of head and neck 1 2 Unknown Status Treatment Recurrent Nasopharyngeal Carcinoma 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 72.9 mg/mL ALOGPS logP 0.29 ALOGPS logP -0.58 Chemaxon logS -0.66 ALOGPS pKa (Strongest Basic) 10.51 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 52.04 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 34.52 m3·mol-1 Chemaxon Polarizability 14.03 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at October 21, 2016 02:25 / Updated at May 14, 2021 01:06