Rheinanthrone is the active metabolite of senna glycoside DB11365 known for its laxative effect . It is commonly produced by plants of the Rheum species .
- Mechanism
- Curator reviewed · 2 references
Rheinanthrone appears to increase macrophage expression of cyclooxygenase 2 (COX2) which increases production of prostaglandin E2 (PGE2). This increase in PGE2 is associated with a subsequent decrease in aquaporin 3 expression. The decreased expression of aquaporin 3 likely restricts reabsorption of water in the large intestine resulting in the laxative effect of rheinanthrone. Rheinanthrone also appears to stimulate peristalsis in the large intestine dependent on contact with the mucosal epithelium.
- Primary indication
- No approved indication.Curator reviewed
- Formula / weight
- C15H10O5 · 270.2369 g/mol (avg)
Resolves to
OZFQHULMMDWMIV-UHFFFAOYSA-NSMILESOC(=O)C1=CC(O)=C2C(CC3=C(C(O)=CC=C3)C2=O)=C1What you can answer from here — as of April 02, 2025
Which companies are running trials of Rheinanthrone, in which indications and phases, and which of those programs are still active?
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