Penimepicycline

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Penimepicycline
Accession Number
DB13264
Description

Penimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients 1. In the classification of the active ingredients included on this list, the classification document states that tetracycline class antibiotics are of medium importance, and are used in humans 2.

Type
Small Molecule
Groups
Experimental
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Structure
Thumb
Weight
Average: 937.03
Monoisotopic: 936.357521681
Chemical Formula
C45H56N6O14S
Synonyms
  • Duamine
  • Hydrocycline
  • Mepicycline penicillinate
  • Penetracyne
  • Penimepiciclina
  • Penimepicycline
  • Pénimépicycline
  • Penimepicyclinum
  • Pipacycline-penicillin V
  • Pipacycline/penicillin V

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe risk or severity of bleeding can be increased when Penimepicycline is combined with Acenocoumarol.
AcitretinThe risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Acitretin is combined with Penimepicycline.
AlitretinoinThe risk or severity of pseudotumor cerebri and elevated intracranial pressure can be increased when Alitretinoin is combined with Penimepicycline.
AlmasilateAlmasilate can cause a decrease in the absorption of Penimepicycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
AluminiumAluminium can cause a decrease in the absorption of Penimepicycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphateAluminium phosphate can cause a decrease in the absorption of Penimepicycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Penimepicycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
AmoxicillinThe therapeutic efficacy of Amoxicillin can be decreased when used in combination with Penimepicycline.
AmpicillinThe therapeutic efficacy of Ampicillin can be decreased when used in combination with Penimepicycline.
AtracuriumThe therapeutic efficacy of Atracurium can be increased when used in combination with Penimepicycline.
Additional Data Available
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  • Severity
    Severity
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Food Interactions
Not Available

Categories

ATC Codes
J01AA10 — Penimepicycline
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as tetracyclines. These are polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Tetracyclines
Sub Class
Not Available
Direct Parent
Tetracyclines
Alternative Parents
Dipeptides / Naphthacenes / Anthracenecarboxylic acids and derivatives / Penicillins / N-acyl-alpha amino acids and derivatives / Tetralins / Aryl ketones / Phenol ethers / Phenoxy compounds / 1-hydroxy-2-unsubstituted benzenoids
show 24 more
Substituents
1,2-aminoalcohol / 1,4-diazinane / 1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / Alcohol / Alkanolamine / Alkyl aryl ether / Alpha-amino acid or derivatives / Alpha-dipeptide / Amine
show 51 more
Molecular Framework
Not Available
External Descriptors
penicillinate salt (CHEBI:75258)

Chemical Identifiers

UNII
3RGQ4B6E87
CAS number
4599-60-4
InChI Key
MEGKRPMNPGTIIG-VNYBMUHKSA-N
InChI
InChI=1S/C29H38N4O9.C16H18N2O5S/c1-28(41)15-5-4-6-18(35)19(15)23(36)20-16(28)13-17-22(31(2)3)24(37)21(26(39)29(17,42)25(20)38)27(40)30-14-33-9-7-32(8-10-33)11-12-34;1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h4-6,16-17,22,34-35,37-38,41-42H,7-14H2,1-3H3,(H,30,40);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t16-,17-,22-,28+,29-;11-,12+,14-/m01/s1
IUPAC Name
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-N-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
SMILES
[H][[email protected]]12SC(C)(C)[[email protected]@H](N1C(=O)[[email protected]]2NC(=O)COC1=CC=CC=C1)C(O)=O.[H][[email protected]@]12C[[email protected]@]3([H])C(=C(O)[[email protected]]1(O)C(=O)C(C(=O)NCN1CCN(CCO)CC1)=C(O)[[email protected]]2N(C)C)C(=O)C1=C(O)C=CC=C1[[email protected]@]3(C)O

References

General References
  1. Health Canada Approved ingredients list [Link]
  2. Categorizing Antimicrobials on List A Government of Canada [Link]
KEGG Drug
D07233
ChemSpider
12977481
ChEBI
75258
ChEMBL
CHEMBL3833378
Wikipedia
Penimepicycline

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility8.04 mg/mLALOGPS
logP-0.7ALOGPS
logP-4.5ChemAxon
logS-1.9ALOGPS
pKa (Strongest Acidic)3.34ChemAxon
pKa (Strongest Basic)9.27ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area194.34 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity154.26 m3·mol-1ChemAxon
Polarizability61.87 Å3ChemAxon
Number of Rings8ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on June 23, 2017 14:38 / Updated on June 12, 2020 10:53

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