Ormeloxifene

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Ormeloxifene
DrugBank Accession Number
DB13310
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 457.614
Monoisotopic: 457.261693991
Chemical Formula
C30H35NO3
Synonyms
  • Ormeloxifene

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Ormeloxifene is combined with Abciximab.
AcenocoumarolThe risk or severity of adverse effects can be increased when Ormeloxifene is combined with Acenocoumarol.
AcetaminophenThe metabolism of Ormeloxifene can be increased when combined with Acetaminophen.
AcetazolamideThe metabolism of Ormeloxifene can be increased when combined with Acetazolamide.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Ormeloxifene.
AlpelisibThe metabolism of Ormeloxifene can be increased when combined with Alpelisib.
AlteplaseThe risk or severity of adverse effects can be increased when Ormeloxifene is combined with Alteplase.
AminoglutethimideThe metabolism of Ormeloxifene can be increased when combined with Aminoglutethimide.
AmobarbitalThe metabolism of Ormeloxifene can be increased when combined with Amobarbital.
AmoxicillinThe therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Amoxicillin.
Interactions
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Food Interactions
Not Available

Categories

ATC Codes
G03XC04 — Ormeloxifene
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as 7-o-methylated isoflavonoids. These are isoflavonoids with methoxy groups attached to the C7 atom of the isoflavonoid backbone. Isoflavonoids are natural products derived from 3-phenylchromen-4-one.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Isoflavonoids
Sub Class
O-methylated isoflavonoids
Direct Parent
7-O-methylated isoflavonoids
Alternative Parents
Neoflavans / Isoflavans / Stilbenes / 2,2-dimethyl-1-benzopyrans / Phenoxy compounds / Anisoles / Alkyl aryl ethers / N-alkylpyrrolidines / Trialkylamines / Oxacyclic compounds
show 3 more
Substituents
1-benzopyran / 2,2-dimethyl-1-benzopyran / 7-methoxyisoflavonoid-skeleton / Alkyl aryl ether / Amine / Anisole / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Benzopyran
show 21 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
9512UKZ352
CAS number
31477-60-8
InChI Key
XZEUAXYWNKYKPL-WDYNHAJCSA-N
InChI
InChI=1S/C30H35NO3/c1-30(2)29(23-9-5-4-6-10-23)28(26-16-15-25(32-3)21-27(26)34-30)22-11-13-24(14-12-22)33-20-19-31-17-7-8-18-31/h4-6,9-16,21,28-29H,7-8,17-20H2,1-3H3/t28-,29+/m1/s1
IUPAC Name
1-(2-{4-[(3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-3,4-dihydro-2H-1-benzopyran-4-yl]phenoxy}ethyl)pyrrolidine
SMILES
[H][C@@]1(C2=CC=C(OCCN3CCCC3)C=C2)C2=C(OC(C)(C)[C@@]1([H])C1=CC=CC=C1)C=C(OC)C=C2

References

General References
Not Available
ChemSpider
32935
BindingDB
50219398
ChEMBL
CHEMBL301327
ZINC
ZINC000001730388
Wikipedia
Ormeloxifene

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000102 mg/mLALOGPS
logP6.75ALOGPS
logP6.03ChemAxon
logS-6.6ALOGPS
pKa (Strongest Basic)9ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area30.93 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity137.19 m3·mol-1ChemAxon
Polarizability53.38 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on June 23, 2017 20:39 / Updated on February 21, 2021 18:54