Ormeloxifene is a selective estrogen receptor modulator used as a non-hormonal, non-steroidal oral contraceptive. Similar to other selective estrogen receptor modulators (SERMs), ormeloxifene has estrogenic activity in the vagina, bone, cardiovascular, and central nervous system tissues, and anti-estrogenic activity in the uterus and breast.
- Mechanism
- Curator reviewed · 1 reference
Ormeloxifene has both estrogenic and anti-estrogenic activity. As a contraceptive, ormeloxifene inhibits endometrial receptivity to blastocyst signals. This mechanism inhibits implantation without affecting nidatory estrogen and progesterone, the hypothalamo-pituitary-ovarian axis, follicle maturation, ovulation, mating behavior, gamete transport or fertilization, and the preimplantation development of embryos.
- Formula / weight
- C30H35NO3 · 457.614 g/mol (avg)
- Also known as
- Centchroman
Resolves to
XZEUAXYWNKYKPL-WDYNHAJCSA-NSMILES[H][C@@]1(C2=CC=C(OCCN3CCCC3)C=C2)C2=C(OC(C)(C)[C@@]1([H])C1=CC=CC=C1)C=C(OC)C=C2What you can answer from here — as of December 01, 2022
Which drugs share a target with Ormeloxifene, and which of those have an active Phase 3 trial?
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