This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Magnesium aspartate
DrugBank Accession Number
DB13359
Background

Magnesium aspartate is a magnesium salt of aspartic acid that is commonly used as a mineral supplement. It displays high oral bioavailability and water solubiltiy compared to other magnesium salts such as magnesium citrate, magnesium carbonate and magnesium oxide.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 360.555
Monoisotopic: 360.08666579
Chemical Formula
C8H20MgN2O12
Synonyms
  • (+)-magnesium aspartate tetrahydrate
  • Aspartic acid, magnesium salt
  • Magnesium aspartate
  • Magnesium aspartate tetrahydrate

Pharmacology

Indication

Not Available

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Alendronic acidMagnesium aspartate can cause a decrease in the absorption of Alendronic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
AlfacalcidolThe serum concentration of Magnesium aspartate can be increased when it is combined with Alfacalcidol.
AmiodaroneThe risk or severity of hypotension can be increased when Magnesium aspartate is combined with Amiodarone.
AmlodipineThe risk or severity of hypotension can be increased when Magnesium aspartate is combined with Amlodipine.
AtracuriumThe therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium aspartate.
Atracurium besylateThe therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium aspartate.
BepridilThe risk or severity of hypotension can be increased when Magnesium aspartate is combined with Bepridil.
Botulinum toxin type AThe therapeutic efficacy of Botulinum toxin type A can be increased when used in combination with Magnesium aspartate.
Botulinum toxin type BThe risk or severity of adverse effects can be increased when Magnesium aspartate is combined with Botulinum toxin type B.
CalcifediolThe serum concentration of Magnesium aspartate can be increased when it is combined with Calcifediol.
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Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Dermamed Nutrition for troubled skinMagnesium aspartate (50 mg/1.5g) + Ascorbic acid (30 mg/1.5g) + Copper Cu-64 (1 mg/1.5g) + Thiamine chloride (20 mg/1.5g) + Vitamin A (150 [iU]/1.5g) + Vitamin D (150 [iU]/1.5g) + Zinc gluconate (10 mg/1.5g)Capsule, gelatin coatedOralDermaMed2019-09-18Not applicableUS flag
FATIGON TABLETMagnesium aspartate (100 mg) + Cyanocobalamin (100 mcg) + Potassium aspartate (100 mg) + Pyridoxine hydrochloride (50 mg) + Thiamine hydrochloride (100 mg) + Vitamin E (30 IU)TabletOralTHE ZYFAS MEDICAL CO.,2020-09-08Not applicableMalaysia flag
RENAPARMagnesium aspartate (100 mg) + Potassium aspartate (300 mg)Tablet, film coatedOralPratapa Nirmala2017-02-272027-02-27Indonesia flag
TROMCARDIN AMPUL, 25 ADETMagnesium aspartate (0.5 g) + Potassium aspartate (0.5 g)SolutionIntravenousADEKA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
TROMCARDIN AMPUL, 5 ADETMagnesium aspartate (0.5 g) + Potassium aspartate (0.5 g)SolutionIntravenousADEKA İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

ATC Codes
A12CC05 — Magnesium aspartate
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
R17X820ROL
CAS number
7018-07-7
InChI Key
CRSJYWPXKKSOCQ-CBAPHJFVSA-L
InChI
InChI=1S/2C4H7NO4.Mg.4H2O/c2*5-2(4(8)9)1-3(6)7;;;;;/h2*2H,1,5H2,(H,6,7)(H,8,9);;4*1H2/q;;+2;;;;/p-2/t2*2-;;;;;/m00...../s1
IUPAC Name
magnesium(2+) bis((2S)-2-amino-3-carboxypropanoate) tetrahydrate
SMILES
O.O.O.O.[Mg++].N[C@@H](CC(O)=O)C([O-])=O.N[C@@H](CC(O)=O)C([O-])=O

References

General References
  1. TITCK Product Information: Tromcardin (potassium aspartate/magnesium aspartate) solution for injection [Link]
PubChem Substance
347911448
ChemSpider
34993538
RxNav
142131
Wikipedia
Magnesium_aspartate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Capsule, gelatin coatedOral
TabletOral
Capsule
SolutionIntravenous
Tablet, film coatedOral
Injection, solutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.98 mg/mLALOGPS
logP-3.8ALOGPS
logP-3.5ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)1.7ChemAxon
pKa (Strongest Basic)9.61ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area103.45 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity37.37 m3·mol-1ChemAxon
Polarizability10.99 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at June 23, 2017 20:40 / Updated at November 03, 2020 01:20