Fenyramidol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Fenyramidol is a muscle relaxant indicated in the symptomatic treatment of musculoskeletal pain and spasms.

Generic Name
Fenyramidol
DrugBank Accession Number
DB13414
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 214.268
Monoisotopic: 214.110613079
Chemical Formula
C13H14N2O
Synonyms
  • Feniramidol
  • Fenyramidol
  • Fenyramidolum
  • Phenyramidol
External IDs
  • IN 511
  • MJ 505

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Symptomatic treatment ofPain••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Fenyramidol.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Fenyramidol.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Fenyramidol.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with Fenyramidol.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with Fenyramidol.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Phenyramidol hydrochlorideM574V6XQH7326-43-2HYYDHUILGLWOOP-UHFFFAOYSA-N

Categories

ATC Codes
M03BX30 — Fenyramidol
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as aminopyridines and derivatives. These are organic heterocyclic compounds containing an amino group attached to a pyridine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Aminopyridines and derivatives
Direct Parent
Aminopyridines and derivatives
Alternative Parents
Secondary alkylarylamines / Imidolactams / Benzene and substituted derivatives / Heteroaromatic compounds / Secondary alcohols / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives / Aromatic alcohols
Substituents
Alcohol / Amine / Aminopyridine / Aromatic alcohol / Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Heteroaromatic compound / Hydrocarbon derivative / Imidolactam
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
R3V02WL7O3
CAS number
553-69-5
InChI Key
ZEAJXCPGHPJVNP-UHFFFAOYSA-N
InChI
InChI=1S/C13H14N2O/c16-12(11-6-2-1-3-7-11)10-15-13-8-4-5-9-14-13/h1-9,12,16H,10H2,(H,14,15)
IUPAC Name
1-phenyl-2-[(pyridin-2-yl)amino]ethan-1-ol
SMILES
OC(CNC1=NC=CC=C1)C1=CC=CC=C1

References

General References
  1. TITCK Product Information: Draxol (feniramidol hydrochloride) film-coated tablets [Link]
  2. TITCK Product Information: Phebdol (feniramidol hydrochloride) solution for intramuscular injection [Link]
ChemSpider
9098
BindingDB
235694
ChEBI
134888
ChEMBL
CHEMBL1697767
Wikipedia
Fenyramidol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, coatedOral400 mg
Tablet, film coatedOral400 mg
InjectionIntramuscular800 mg/3ml
Injection, solutionIntramuscular800 mg/3ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.94 mg/mLALOGPS
logP2.01ALOGPS
logP1.92Chemaxon
logS-2.4ALOGPS
pKa (Strongest Acidic)14.1Chemaxon
pKa (Strongest Basic)6.61Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area45.15 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity64.98 m3·mol-1Chemaxon
Polarizability23.69 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0a4i-6900000000-deb4ed85c87dea4ed8d1
GC-MS Spectrum - EI-BGC-MSsplash10-0a4i-6900000000-d9b37fd7b9c02cab5313
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0fr7-4930000000-f776665dd7af54a67f58
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4l-4920000000-2ac10f4dcee740ef4c1a
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0kdi-6900000000-4690f49640fa95031445
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9400000000-e1703f3de9f74473de03
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9400000000-24198f74ec82a008043c
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-016r-6900000000-ea97076d73f999938718
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-144.18793
predicted
DeepCCS 1.0 (2019)
[M+H]+146.58348
predicted
DeepCCS 1.0 (2019)
[M+Na]+152.81543
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:41 / Updated at June 02, 2021 20:04