Midecamycin is a macrolide antibiotic used to treat a variety of infections caused by susceptible bacteria. Midecamycin is a naturally occurring 16-membered macrolide that fits under the category of acetoxy-substituted macrolide antibiotics.
- Mechanism
- Curator reviewed · 1 reference
Midecamycin, as part of the macrolides, act by inhibiting bacterial protein synthesis. More specifically, midecamycin inhibits bacterial growth by targetting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. The presence of mutations in the 50S RNA can prevent midecamycin binding. Midecamycin is a broad spectrum antibiotic and thus, it can interact with different bacteria.
- Primary indication
- Midecamycin was used for the treatment of infections in the oral cavity, upper and lower respiratory tracts and skin and soft tissue infections.Curator reviewed · 7 structured indications
- Formula / weight
- C41H67NO15 · 813.979 g/mol (avg)
- Also known as
- Espinomycin A · Medecamycin A1 · Medemycin A1 · Midecamycin A1 · Momicine
- Code names
- NSC-154011 · SF-837 · SF-837A1 · YL-704B1
Resolves to
DMUAPQTXSSNEDD-QALJCMCCSA-NSMILES[H][C@@]1(C[C@@](C)(O)[C@@H](OC(=O)CC)[C@H](C)O1)O[C@@H]1[C@@H](C)O[C@@]([H])(O[C@H]2[C@@H](CC=O)C[C@@H](C)[C@@H](O)\C=C\C=C\C[C@@H](C)OC(=O)C[C@@]([H])(OC(=O)CC)[C@@H]2OC)[C@H](O)[C@H]1N(C)CWhat you can answer from here — as of September 13, 2026
Which other approved drugs treat the same conditions as Midecamycin, and which companies have late-stage candidates in those indications?
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