Metergoline

DB13520ApprovedSmall molecule

Metergoline is an ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. It is often used in situations where inhibition of prolactin is desirable. Its use has been studied in various clinical settings such as a treatment for seasonal affective disorder, prolactin hormone regulation due to its inhibitory effect on prolactin release, premenstrual dysphoric disorder in women and antianxiety...

Chemical structure of Metergoline
Formula / weight
C25H29N3O2 · 403.526 g/mol (avg)
Code names
FI-6337

Resolves to

Compound
UNII1501393LY5CAS17692-51-2ChEMBLCHEMBL19215ChEBI64216PubChem28693KEGGD07218
Clinical / RWD
RxNorm6834ATCG02CB05
Structure
InChIKeyWZHJKEUHNJHDLS-QTGUNEKASA-NSMILES[H][C@@]12CC3=CN(C)C4=CC=CC(=C34)[C@@]1([H])C[C@@H](CNC(=O)OCC1=CC=CC=C1)CN2C
Targets
P28223HTR2AP41595HTR2BP28221HTR1DP47898HTR5AP30939HTR1FP28566HTR1EP28222HTR1BP28335HTR2C+1 more

What you can answer from here — as of January 29, 2025

9Protein targetsEach mapped to UniProt, with action and pharmacological action
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1,171Drug interactionsStructured to mechanism, not free text
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7Structured indicationsCondition, population, route and combination as fields, not prose
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2ContraindicationsEach with its own population and attribute set
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2Marketed productsAcross 1 country and 1 labeller
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1ATC codeIncluding every combination product, plus 21 drug categories
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26+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Metergoline, and which of those have an active Phase 3 trial?

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