Nizofenone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name

Nizofenone

DrugBank Accession Number

DB13546

Background

Not Available

Type

Small Molecule

Groups

Experimental

Structure

Similar Structures

Weight: Average: 412.87
Monoisotopic: 412.1302183
Chemical Formula: C₂₁H₂₁ClN₄O₃

Synonyms

Nizofenone

Pharmacology

Indication: Not Available
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Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Acebutolol	Acebutolol may increase the arrhythmogenic activities of Nizofenone.
Acetyldigitoxin	Acetyldigitoxin may increase the arrhythmogenic activities of Nizofenone.
Acrivastine	The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Nizofenone.
Adenosine	Adenosine may increase the arrhythmogenic activities of Nizofenone.
Ajmaline	Ajmaline may increase the arrhythmogenic activities of Nizofenone.
Alfuzosin	The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Nizofenone.
Alimemazine	The risk or severity of QTc prolongation can be increased when Alimemazine is combined with Nizofenone.
Amantadine	The risk or severity of QTc prolongation can be increased when Amantadine is combined with Nizofenone.
Amifampridine	The risk or severity of QTc prolongation can be increased when Amifampridine is combined with Nizofenone.
Amiodarone	The risk or severity of adverse effects can be increased when Amiodarone is combined with Nizofenone.

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Food Interactions

Not Available

Chemical Identifiers

UNII: 7A2NOC3R88
CAS number: 54533-85-6
InChI Key: WZGBZLHGOVJDET-UHFFFAOYSA-N
InChI: InChI=1S/C21H21ClN4O3/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22/h5-13H,3-4,14H2,1-2H3
IUPAC Name: ({1-[2-(2-chlorobenzoyl)-4-nitrophenyl]-1H-imidazol-2-yl}methyl)diethylamine
SMILES: CCN(CC)CC1=NC=CN1C1=C(C=C(C=C1)N(=O)=O)C(=O)C1=CC=CC=C1Cl

References

General References

Not Available

External Links

ChemSpider: 4357
ChEBI: 135668
ChEMBL: CHEMBL2106822
ZINC: ZINC000000538096
Wikipedia: Nizofenone

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers: Not Available
Packagers: Not Available
Dosage Forms: Not Available
Prices: Not Available
Patents: Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.00733 mg/mL	ALOGPS
logP	4.2	ALOGPS
logP	4.47	Chemaxon
logS	-4.8	ALOGPS
pKa (Strongest Basic)	6.73	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	5	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	83.95 Å²	Chemaxon
Rotatable Bond Count	8	Chemaxon
Refractivity	124.08 m³·mol^-1	Chemaxon
Polarizability	41.25 Å³	Chemaxon
Number of Rings	3	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	Yes	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

Drug created at June 23, 2017 20:44 / Updated at February 21, 2021 18:54

Nizofenone

Identification

Structure for Nizofenone (DB13546)

Pharmacology

Interactions

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra