Prajmaline

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Prajmaline
DrugBank Accession Number
DB13555
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 369.528
Monoisotopic: 369.253654731
Chemical Formula
C23H33N2O2
Synonyms
  • Prajmalium

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololAcebutolol may increase the arrhythmogenic activities of Prajmaline.
AcetyldigitoxinAcetyldigitoxin may increase the arrhythmogenic activities of Prajmaline.
AcrivastineThe risk or severity of QTc prolongation can be increased when Acrivastine is combined with Prajmaline.
AdenosineAdenosine may increase the arrhythmogenic activities of Prajmaline.
AjmalineAjmaline may increase the arrhythmogenic activities of Prajmaline.
Food Interactions
Not Available

Categories

ATC Codes
C01BA08 — Prajmaline
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as ajmaline-sarpagine alkaloids. These are organic compounds containing either of the ajmalan, sarpagan skeleton, or derivative thereof. The Sarpagine (Akuammidine) group, based on the sarpagan nucleus, arises from bond formation between C-16 and C-5 of the corynantheine precursor. Ajmaline alkaloids are based on a 17,19-secoyohimban skeleton (oxayohimban) which is invariably present as an ether.
Kingdom
Organic compounds
Super Class
Alkaloids and derivatives
Class
Ajmaline-sarpagine alkaloids
Sub Class
Not Available
Direct Parent
Ajmaline-sarpagine alkaloids
Alternative Parents
Beta carbolines / Quinolizidines / Quinuclidines / Dialkylarylamines / Aralkylamines / Azepanes / Benzenoids / Piperidines / Tetraalkylammonium salts / Hemiaminals
show 7 more
Substituents
Alcohol / Alkanolamine / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Azepane / Benzenoid / Beta-carboline / Cyclic alcohol
show 21 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
75934UD4GJ
CAS number
35080-11-6
InChI Key
UAUHEPXILIZYCU-ALHOSYKFSA-N
InChI
InChI=1S/C23H33N2O2/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3/q+1/t13-,14-,17-,18-,19-,20-,21+,22+,23+,25-/m0/s1
IUPAC Name
(1R,9R,10S,12R,13S,14R,15R,16S,17S,18R)-13-ethyl-14,18-dihydroxy-8-methyl-15-propyl-8,15-diazahexacyclo[14.2.1.0^{1,9}.0^{2,7}.0^{10,15}.0^{12,17}]nonadeca-2(7),3,5-trien-15-ium
SMILES
CCC[N@@+]12[C@H]3C[C@]45[C@H](O)[C@H]3[C@@H](C[C@H]1[C@@H]4N(C)C1=C5C=CC=C1)[C@H](CC)[C@H]2O

References

General References
Not Available
ChemSpider
34986954
RxNav
8622
ChEBI
135560
ZINC
ZINC000252462538
Wikipedia
Prajmaline

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0299 mg/mLALOGPS
logP2.24ALOGPS
logP-1.4Chemaxon
logS-4.1ALOGPS
pKa (Strongest Acidic)12.01Chemaxon
pKa (Strongest Basic)-0.54Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area43.7 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity117.75 m3·mol-1Chemaxon
Polarizability42.74 Å3Chemaxon
Number of Rings6Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-193.6844
predicted
DeepCCS 1.0 (2019)
[M+H]+195.5324
predicted
DeepCCS 1.0 (2019)
[M+Na]+201.14653
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:44 / Updated at June 12, 2020 16:53