This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Phenazocine
- DrugBank Accession Number
- DB13606
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Phenazocine (DB13606)
- Weight
- Average: 321.464
Monoisotopic: 321.209264493 - Chemical Formula
- C22H27NO
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of adverse effects can be increased when Phenazocine is combined with 1,2-Benzodiazepine. Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Phenazocine. Acetophenazine The risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Phenazocine. Aclidinium The risk or severity of adverse effects can be increased when Aclidinium is combined with Phenazocine. Agomelatine The risk or severity of adverse effects can be increased when Agomelatine is combined with Phenazocine. Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Phenazocine. Alimemazine The risk or severity of hypotension and CNS depression can be increased when Alimemazine is combined with Phenazocine. Alloin The therapeutic efficacy of Alloin can be decreased when used in combination with Phenazocine. Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Phenazocine. Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Phenazocine. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- ATC Codes
- N02AD02 — Phenazocine
- Drug Categories
- Alkaloids
- Analgesics
- Benzomorphan Derivatives
- Benzomorphans
- Central Nervous System Agents
- Central Nervous System Depressants
- Morphinans
- Narcotics
- Nervous System
- Opiate Alkaloids
- Opioids
- Peripheral Nervous System Agents
- Phenanthrenes
- Sensory System Agents
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 2,6-dimethyl-3-benzazocines. These are aromatic compounds containing a 6,7-benzomorphan skeleton, which is substituted by methyl group at the 2- and 6-positions.
- Kingdom
- Organic compounds
- Super Class
- Alkaloids and derivatives
- Class
- 6,7-benzomorphans
- Sub Class
- 2,6-dimethyl-3-benzazocines
- Direct Parent
- 2,6-dimethyl-3-benzazocines
- Alternative Parents
- 4-hydroxy-6,7-benzomorphans / Benzazocines / Tetralins / Phenethylamines / Aralkylamines / 1-hydroxy-2-unsubstituted benzenoids / Piperidines / Trialkylamines / Azacyclic compounds / Organopnictogen compounds show 2 more
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / 2,6-dimethyl-3-benzazocine / 4-hydroxy-6,7-benzomorphan / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzazocine / Benzenoid / Hydrocarbon derivative show 12 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- benzazocine (CHEBI:8056)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- J0ND6N0AQC
- CAS number
- 58073-76-0
- InChI Key
- ZQHYKVKNPWDQSL-KNXBSLHKSA-N
- InChI
- InChI=1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3/t16-,21+,22+/m0/s1
- IUPAC Name
- (1R,9R,13R)-1,13-dimethyl-10-(2-phenylethyl)-10-azatricyclo[7.3.1.0^{2,7}]trideca-2,4,6-trien-4-ol
- SMILES
- C[C@H]1[C@H]2CC3=CC=C(O)C=C3[C@]1(C)CCN2CCC1=CC=CC=C1
References
- General References
- Not Available
- External Links
- KEGG Compound
- C11790
- ChemSpider
- 391631
- 8119
- ChEBI
- 8056
- ChEMBL
- CHEMBL316632
- ZINC
- ZINC000001481896
- Wikipedia
- Phenazocine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00743 mg/mL ALOGPS logP 4.93 ALOGPS logP 4.08 Chemaxon logS -4.6 ALOGPS pKa (Strongest Acidic) 9.96 Chemaxon pKa (Strongest Basic) 10.86 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 23.47 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 100.05 m3·mol-1 Chemaxon Polarizability 37.92 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:45 / Updated at June 12, 2020 16:53