Clorexolone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name

Clorexolone

DrugBank Accession Number

DB13617

Background

Not Available

Type

Small Molecule

Groups

Experimental

Structure

Similar Structures

Weight: Average: 328.81
Monoisotopic: 328.0648413
Chemical Formula: C₁₄H₁₇ClN₂O₃S

Synonyms

Clorexolone

Pharmacology

Indication: Not Available
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Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Abacavir	Clorexolone may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Acarbose	The therapeutic efficacy of Acarbose can be increased when used in combination with Clorexolone.
Aceclofenac	Clorexolone may increase the excretion rate of Aceclofenac which could result in a lower serum level and potentially a reduction in efficacy.
Acemetacin	The therapeutic efficacy of Clorexolone can be decreased when used in combination with Acemetacin.
Acetaminophen	Clorexolone may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
Acetohexamide	The therapeutic efficacy of Acetohexamide can be increased when used in combination with Clorexolone.
Acetylsalicylic acid	Acetylsalicylic acid may decrease the excretion rate of Clorexolone which could result in a higher serum level.
Aclidinium	Clorexolone may increase the excretion rate of Aclidinium which could result in a lower serum level and potentially a reduction in efficacy.
Acrivastine	Clorexolone may increase the excretion rate of Acrivastine which could result in a lower serum level and potentially a reduction in efficacy.
Acyclovir	Clorexolone may increase the excretion rate of Acyclovir which could result in a lower serum level and potentially a reduction in efficacy.

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Food Interactions

Not Available

Chemical Identifiers

UNII: Q2PLT3FS05
CAS number: 2127-01-7
InChI Key: VPMWFZKOWULPGT-UHFFFAOYSA-N
InChI: InChI=1S/C14H17ClN2O3S/c15-12-6-9-8-17(10-4-2-1-3-5-10)14(18)11(9)7-13(12)21(16,19)20/h6-7,10H,1-5,8H2,(H2,16,19,20)
IUPAC Name: 6-chloro-2-cyclohexyl-3-oxo-2,3-dihydro-1H-isoindole-5-sulfonamide
SMILES: NS(=O)(=O)C1=C(Cl)C=C2CN(C3CCCCC3)C(=O)C2=C1

References

General References

Not Available

External Links

ChemSpider: 15615
ChEBI: 31421
ChEMBL: CHEMBL2106167
ZINC: ZINC000000001199
Wikipedia: Clorexolone

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers: Not Available
Packagers: Not Available
Dosage Forms: Not Available
Prices: Not Available
Patents: Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0803 mg/mL	ALOGPS
logP	2.61	ALOGPS
logP	2.03	Chemaxon
logS	-3.6	ALOGPS
pKa (Strongest Acidic)	8.85	Chemaxon
pKa (Strongest Basic)	-1.2	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	3	Chemaxon
Hydrogen Donor Count	1	Chemaxon
Polar Surface Area	80.47 Å²	Chemaxon
Rotatable Bond Count	2	Chemaxon
Refractivity	81.46 m³·mol^-1	Chemaxon
Polarizability	33.36 Å³	Chemaxon
Number of Rings	3	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

Drug created at June 23, 2017 20:45 / Updated at February 21, 2021 18:54

Clorexolone

Identification

Structure for Clorexolone (DB13617)

Pharmacology

Interactions

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra