This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Tiracizine
- DrugBank Accession Number
- DB13635
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Tiracizine (DB13635)
- Weight
- Average: 367.449
Monoisotopic: 367.189591677 - Chemical Formula
- C21H25N3O3
- Synonyms
- Tiracizina
- Tiracizine
- Tiracizinum
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol Acebutolol may increase the arrhythmogenic activities of Tiracizine. Acetyldigitoxin Acetyldigitoxin may increase the arrhythmogenic activities of Tiracizine. Adenosine Adenosine may increase the arrhythmogenic activities of Tiracizine. Ajmaline Ajmaline may increase the arrhythmogenic activities of Tiracizine. Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Tiracizine. Amlodipine Amlodipine may increase the arrhythmogenic activities of Tiracizine. Atenolol Atenolol may increase the arrhythmogenic activities of Tiracizine. Atropine Atropine may increase the arrhythmogenic activities of Tiracizine. Bepridil Bepridil may increase the arrhythmogenic activities of Tiracizine. Betaxolol Betaxolol may increase the arrhythmogenic activities of Tiracizine. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- ATC Codes
- C01EB11 — Tiracizine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as dibenzazepines. These are compounds with two benzene rings connected by an azepine ring. Azepine is an unsaturated seven-member heterocycle with one nitrogen atom replacing a carbon atom.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzazepines
- Sub Class
- Dibenzazepines
- Direct Parent
- Dibenzazepines
- Alternative Parents
- Alpha amino acids and derivatives / Azepines / Benzenoids / Tertiary carboxylic acid amides / Carbamate esters / Trialkylamines / Organic carbonic acids and derivatives / Azacyclic compounds / Organopnictogen compounds / Organic oxides show 2 more
- Substituents
- Alpha-amino acid or derivatives / Amine / Amino acid or derivatives / Aromatic heteropolycyclic compound / Azacycle / Azepine / Benzenoid / Carbamic acid ester / Carbonic acid derivative / Carbonyl group show 13 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9UUO2T61K7
- CAS number
- 83275-56-3
- InChI Key
- KJAMZCVTJDTESW-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H25N3O3/c1-4-27-21(26)22-17-12-11-16-10-9-15-7-5-6-8-18(15)24(19(16)13-17)20(25)14-23(2)3/h5-8,11-13H,4,9-10,14H2,1-3H3,(H,22,26)
- IUPAC Name
- ethyl N-{2-[2-(dimethylamino)acetyl]-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl}carbamate
- SMILES
- CCOC(=O)NC1=CC2=C(CCC3=CC=CC=C3N2C(=O)CN(C)C)C=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 64392
- BindingDB
- 50146373
- ChEBI
- 135549
- ChEMBL
- CHEMBL1625260
- ZINC
- ZINC000000538471
- Wikipedia
- Tiracizine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0501 mg/mL ALOGPS logP 2.76 ALOGPS logP 3.4 ChemAxon logS -3.9 ALOGPS pKa (Strongest Acidic) 13.05 ChemAxon pKa (Strongest Basic) 7.11 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 61.88 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 106.76 m3·mol-1 ChemAxon Polarizability 40.26 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:45 / Updated at February 21, 2021 18:54