Mosapramine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Mosapramine
DrugBank Accession Number
DB13676
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 479.07
Monoisotopic: 478.2499395
Chemical Formula
C28H35ClN4O
Synonyms
  • Mosapramine

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Mosapramine.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Mosapramine.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Mosapramine.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with Mosapramine.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with Mosapramine.
Food Interactions
Not Available

Categories

ATC Codes
N05AX10 — Mosapramine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as dibenzazepines. These are compounds with two benzene rings connected by an azepine ring. Azepine is an unsaturated seven-member heterocycle with one nitrogen atom replacing a carbon atom.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzazepines
Sub Class
Dibenzazepines
Direct Parent
Dibenzazepines
Alternative Parents
Alkyldiarylamines / Alpha amino acids and derivatives / Azaspirodecane derivatives / Imidazopyridines / Azepines / Aryl chlorides / Piperidines / Benzenoids / Imidazolidinones / Trialkylamines
show 8 more
Substituents
Alkyldiarylamine / Alpha-amino acid or derivatives / Amine / Amino acid or derivatives / Aromatic heteropolycyclic compound / Aryl chloride / Aryl halide / Azacycle / Azaspirodecane / Azepine
show 23 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
04UZQ7O9SJ
CAS number
89419-40-9
InChI Key
PXUIZULXJVRBPC-UHFFFAOYSA-N
InChI
InChI=1S/C28H35ClN4O/c29-23-12-11-22-10-9-21-6-1-2-7-24(21)32(25(22)20-23)16-5-15-31-18-13-28(14-19-31)27(34)30-26-8-3-4-17-33(26)28/h1-2,6-7,11-12,20,26H,3-5,8-10,13-19H2,(H,30,34)
IUPAC Name
1'-(3-{14-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}propyl)-hexahydro-1H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
SMILES
ClC1=CC2=C(CCC3=CC=CC=C3N2CCCN2CCC3(CC2)N2CCCCC2NC3=O)C=C1

References

General References
Not Available
ChemSpider
4107
ChEBI
135775
ChEMBL
CHEMBL2106650
Wikipedia
Mosapramine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0179 mg/mLALOGPS
logP4.68ALOGPS
logP4.81Chemaxon
logS-4.4ALOGPS
pKa (Strongest Acidic)11.7Chemaxon
pKa (Strongest Basic)8.65Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area38.82 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity138.73 m3·mol-1Chemaxon
Polarizability53.79 Å3Chemaxon
Number of Rings6Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0000900000-f2f2ab4febdf518a4f49
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0000900000-1e4b2c60062d121d2a97
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0010900000-437897294c51dbee97a5
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-3000900000-b07faf9ae612ea0743e2
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-003r-9201800000-33ed2850ed26885c1389
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0622900000-25aecba3964c6c96e06f
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-212.4506
predicted
DeepCCS 1.0 (2019)
[M+H]+214.93408
predicted
DeepCCS 1.0 (2019)
[M+Na]+222.09526
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:46 / Updated at February 21, 2021 18:54