Sodium tartrate

Identification

Name
Sodium tartrate
Accession Number
DB13707
Description

Sodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals. It is obtained as a byproduct of wine manufacturing. Sodium tartrate is generally recognized as safe (GRAS) as a direct human food ingredient. It acts as an emulsifier and pH control agent in food products 1.

This compound is commonly used as an emulsifier in cheese/cheese spread products and is not to exceed 4% concentration, according to Health Canada regulations 5.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 194.05
Monoisotopic: 193.98032641
Chemical Formula
C4H4Na2O6
Synonyms
  • Bisodium tartrate
  • Disodium L-(+)-tartrate
  • disodium tartrate
  • sodium L-tartrate
  • Tartaric acid, disodium salt
External IDs
  • E-335(II)
  • INS NO.335(II)
  • INS-335(II)

Pharmacology

Indication

It acts as an emulsifier and pH control agent in food products 1, 9. In the laboratory, it is used while performing the Karl Fischer equation, which is used to determine the water content of various substances 10, 1.

Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More
Pharmacodynamics
Not Available
Mechanism of action

Sodium tartrate is a white, crystalline powder, used as an emulsifier and a binding agent. It can be used in jellies, cheeses, sausage casings and any foods which contain fats or oils 8.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity

Abdominal cramps, nausea, and vomiting 2.

Oral LD50 in rats is 4360 mg kg-1 3.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium tartrate.
AclidiniumThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Sodium tartrate is combined with Alloin.
AlmasilateThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Almasilate.
AluminiumThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aluminium.
Aluminium phosphateThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aluminium phosphate.
Aluminum hydroxideThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aluminum hydroxide.
AmantadineThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Sodium tartrate.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

    Learn more
  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

    Learn more
  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

    Learn more
  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

    Learn more
Food Interactions
Not Available

Products

Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Limonade RodecaLiquidOralRodeca Inc., Division Of Technilab Inc.1962-12-312003-09-22Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more

Categories

ATC Codes
A06AD21 — Sodium tartrate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as beta hydroxy acids and derivatives. These are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Hydroxy acids and derivatives
Sub Class
Beta hydroxy acids and derivatives
Direct Parent
Beta hydroxy acids and derivatives
Alternative Parents
Short-chain hydroxy acids and derivatives / Monosaccharides / Fatty acids and conjugates / Dicarboxylic acids and derivatives / Secondary alcohols / Carboxylic acid salts / 1,2-diols / Carboxylic acids / Organic sodium salts / Organic oxides
show 2 more
Substituents
1,2-diol / Alcohol / Aliphatic acyclic compound / Beta-hydroxy acid / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Dicarboxylic acid or derivatives / Fatty acid
show 10 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organic sodium salt (CHEBI:63017)

Chemical Identifiers

UNII
QTO9JB4MDD
CAS number
868-18-8
InChI Key
HELHAJAZNSDZJO-OLXYHTOASA-L
InChI
InChI=1S/C4H6O6.2Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2/t1-,2-;;/m1../s1
IUPAC Name
disodium (2R,3R)-2,3-dihydroxybutanedioate
SMILES
[Na+].[Na+].O[[email protected]]([[email protected]@H](O)C([O-])=O)C([O-])=O

References

General References
  1. Sodium Tartrate, PubChem [Link]
  2. Sodium Tartrate Monograph [Link]
  3. Sodium tartrate, chemspider [Link]
  4. Sodium Tartrate Overiew, Science Direct [Link]
  5. List of Permitted Emulsifying, Gelling, Stabilizing or Thickening Agents (Lists of Permitted Food Additives) [Link]
  6. The pharmacology of sodium tartrate [Link]
  7. Sodium tartrate [Link]
  8. Sodium Tartrate, FCC [Link]
  9. Tartrates [Link]
  10. KARL FISCHER ELECTROMETRIC TITRATION METHOD FOR DETERMINATION OF WATER CONTENT [File]
PubChem Compound
162637
PubChem Substance
347829311
ChemSpider
142788
RxNav
56524
ChEBI
63017
ChEMBL
CHEMBL2107781
Wikipedia
Sodium_tartrate
MSDS
Download (47.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)120MSDS
water solubilitySoluble in cold waterMSDS
Predicted Properties
PropertyValueSource
Water Solubility779.0 mg/mLALOGPS
logP-1.9ALOGPS
logP-1.8ChemAxon
logS0.6ALOGPS
pKa (Strongest Acidic)2.72ChemAxon
pKa (Strongest Basic)-4.3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area120.72 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity47.89 m3·mol-1ChemAxon
Polarizability10.83 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created on June 23, 2017 14:47 / Updated on June 12, 2020 10:53

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Logo pink
Stay in the know!
As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates