NAV

Sodium tartrate

Identification

Generic Name
Sodium tartrate
DrugBank Accession Number
DB13707
Background

Sodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals. It is obtained as a byproduct of wine manufacturing. Sodium tartrate is generally recognized as safe (GRAS) as a direct human food ingredient. It acts as an emulsifier and pH control agent in food products 1.

This compound is commonly used as an emulsifier in cheese/cheese spread products and is not to exceed 4% concentration, according to Health Canada regulations 5.

Type
Small Molecule
Groups
Approved
Structure
Similar Structures
Weight
Average: 194.05
Monoisotopic: 193.98032641
Chemical Formula
C4H4Na2O6
Synonyms
  • Bisodium tartrate
  • Disodium L-(+)-tartrate
  • disodium tartrate
  • sodium L-tartrate
  • Tartaric acid, disodium salt
External IDs
  • E-335(II)
  • INS NO.335(II)
  • INS-335(II)

Pharmacology

Indication

It acts as an emulsifier and pH control agent in food products 1, 9. In the laboratory, it is used while performing the Karl Fischer equation, which is used to determine the water content of various substances 10, 1.

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action

Sodium tartrate is a white, crystalline powder, used as an emulsifier and a binding agent. It can be used in jellies, cheeses, sausage casings and any foods which contain fats or oils 8.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Abdominal cramps, nausea, and vomiting 2.

Oral LD50 in rats is 4360 mg kg-1 3.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium tartrate.
AclidiniumThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Sodium tartrate is combined with Alloin.
AlmasilateThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Almasilate.
Aluminium phosphateThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aluminium phosphate.
Aluminum hydroxideThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aluminum hydroxide.
AmantadineThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Sodium tartrate.
AmiodaroneThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Amiodarone.
Identify potential medication risks
Easily compare up to 40 drugs with our drug interaction checker.
Get severity rating, description, and management advice.
Learn more
Food Interactions
Not Available

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Limonade RodecaLiquid5.6 g / 100 mLOralRodeca Inc., Division Of Technilab Inc.1962-12-312003-09-22Canada flag

Categories

ATC Codes
A06AD21 — Sodium tartrate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as beta hydroxy acids and derivatives. These are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Hydroxy acids and derivatives
Sub Class
Beta hydroxy acids and derivatives
Direct Parent
Beta hydroxy acids and derivatives
Alternative Parents
Short-chain hydroxy acids and derivatives / Monosaccharides / Fatty acids and conjugates / Dicarboxylic acids and derivatives / Secondary alcohols / Carboxylic acid salts / 1,2-diols / Carboxylic acids / Organic sodium salts / Organic oxides
show 2 more
Substituents
1,2-diol / Alcohol / Aliphatic acyclic compound / Beta-hydroxy acid / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Dicarboxylic acid or derivatives / Fatty acid
show 10 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organic sodium salt (CHEBI:63017)
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
QTO9JB4MDD
CAS number
868-18-8
InChI Key
HELHAJAZNSDZJO-OLXYHTOASA-L
InChI
InChI=1S/C4H6O6.2Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2/t1-,2-;;/m1../s1
IUPAC Name
disodium (2R,3R)-2,3-dihydroxybutanedioate
SMILES
[Na+].[Na+].O[C@H]([C@@H](O)C([O-])=O)C([O-])=O

References

General References
  1. Sodium Tartrate, PubChem [Link]
  2. Sodium Tartrate Monograph [Link]
  3. Sodium tartrate, chemspider [Link]
  4. Sodium Tartrate Overiew, Science Direct [Link]
  5. List of Permitted Emulsifying, Gelling, Stabilizing or Thickening Agents (Lists of Permitted Food Additives) [Link]
  6. The pharmacology of sodium tartrate [Link]
  7. Sodium tartrate [Link]
  8. Sodium Tartrate, FCC [Link]
  9. Tartrates [Link]
  10. KARL FISCHER ELECTROMETRIC TITRATION METHOD FOR DETERMINATION OF WATER CONTENT [File]
PubChem Compound
162637
PubChem Substance
347829311
ChemSpider
142788
RxNav
56524
ChEBI
63017
ChEMBL
CHEMBL2107781
Wikipedia
Sodium_tartrate
MSDS
Download (47.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidOral5.6 g / 100 mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)120MSDS
water solubilitySoluble in cold waterMSDS
Predicted Properties
PropertyValueSource
Water Solubility779.0 mg/mLALOGPS
logP-1.9ALOGPS
logP-1.8Chemaxon
logS0.6ALOGPS
pKa (Strongest Acidic)2.72Chemaxon
pKa (Strongest Basic)-4.3Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area120.72 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity47.89 m3·mol-1Chemaxon
Polarizability10.83 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created at June 23, 2017 20:47 / Updated at June 12, 2020 16:53