Mephenoxalone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Mephenoxalone is a muscle relaxant indicated in the treatment of painful muscle spasms and cramps.

Generic Name
Mephenoxalone
DrugBank Accession Number
DB13754
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 223.228
Monoisotopic: 223.084457903
Chemical Formula
C11H13NO4
Synonyms
  • Mefenoxalona
  • Mephenoxalone
  • Mephenoxalonum
External IDs
  • AHR 233
  • CL 27,319
  • OM 518

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatMuscle spasmsCombination Product in combination with: Acetaminophen (DB00316)••••••••••••••••••
Used in combination to treatPainCombination Product in combination with: Acetaminophen (DB00316)••••••••••••••••••
Used in combination for symptomatic treatment ofPainCombination Product in combination with: Acetaminophen (DB00316)••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Mephenoxalone.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Mephenoxalone.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Mephenoxalone.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with Mephenoxalone.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with Mephenoxalone.
Food Interactions
Not Available

Products

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International/Other Brands
Dorsilon / Lenetran / Placidex / Riself / Transpoise / Valanas / Xerene
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DORSILON TABLET, 1000 ADETMephenoxalone (200 mg) + Acetaminophen (450 mg)TabletSANDOZ İLAÇ SAN. VE TİC. A.Ş.1991-09-11Not applicableTurkey flag
DORSILON TABLET, 20 ADETMephenoxalone (200 mg) + Acetaminophen (450 mg)TabletSANDOZ İLAÇ SAN. VE TİC. A.Ş.1991-09-11Not applicableTurkey flag
DORSILON TABLET, 60 ADETMephenoxalone (200 mg) + Acetaminophen (450 mg)TabletSANDOZ İLAÇ SAN. VE TİC. A.Ş.1991-09-11Not applicableTurkey flag

Categories

ATC Codes
N05BX01 — Mephenoxalone
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Phenol ethers
Sub Class
Anisoles
Direct Parent
Anisoles
Alternative Parents
Phenoxy compounds / Methoxybenzenes / Alkyl aryl ethers / Oxazolidinones / Carbamate esters / Organic carbonic acids and derivatives / Oxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds
show 3 more
Substituents
Alkyl aryl ether / Anisole / Aromatic heteromonocyclic compound / Azacycle / Carbamic acid ester / Carbonic acid derivative / Carbonyl group / Ether / Hydrocarbon derivative / Methoxybenzene
show 12 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
CZ87T54W8W
CAS number
70-07-5
InChI Key
ZMNSRFNUONFLSP-UHFFFAOYSA-N
InChI
InChI=1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)
IUPAC Name
5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
SMILES
COC1=C(OCC2CNC(=O)O2)C=CC=C1

References

General References
  1. TITCK Product Information: Dorsilon (acetaminophen/mephenoxalone) oral tablets [Link]
ChemSpider
6021
ChEBI
134916
ChEMBL
CHEMBL2104790
Wikipedia
Mephenoxalone

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility4.93 mg/mLALOGPS
logP0.8ALOGPS
logP1.19Chemaxon
logS-1.7ALOGPS
pKa (Strongest Acidic)12.68Chemaxon
pKa (Strongest Basic)-4.6Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area56.79 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity55.7 m3·mol-1Chemaxon
Polarizability22.22 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - EI-BGC-MSsplash10-00di-8910000000-e3415068da48afc84e9d
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0fk9-0940000000-ca5717bc6a83cf0d1c77
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9100000000-bb3c3071636d6d235d6a
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4l-7900000000-8628931011ff270f0482
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-6910000000-cceaef8df132c8809018
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-007o-9400000000-25b569324b90770b9312
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-052g-9300000000-d179deae42adb102a293
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-144.72014
predicted
DeepCCS 1.0 (2019)
[M+H]+147.26445
predicted
DeepCCS 1.0 (2019)
[M+Na]+155.8637
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:48 / Updated at May 22, 2021 06:01