Dixyrazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Dixyrazine
DrugBank Accession Number
DB13784
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 427.61
Monoisotopic: 427.229348489
Chemical Formula
C24H33N3O2S
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Dixyrazine.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Dixyrazine.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Dixyrazine.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Dixyrazine.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Dixyrazine.
Food Interactions
Not Available

Products

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Categories

ATC Codes
N05AB01 — Dixyrazine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzothiazines
Sub Class
Phenothiazines
Direct Parent
Phenothiazines
Alternative Parents
Alkyldiarylamines / Diarylthioethers / N-alkylpiperazines / Benzenoids / 1,4-thiazines / Trialkylamines / Dialkyl ethers / Azacyclic compounds / Primary alcohols / Organopnictogen compounds
show 1 more
Substituents
1,4-diazinane / Alcohol / Alkyldiarylamine / Amine / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Benzenoid / Dialkyl ether / Diarylthioether
show 16 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
7H368W3AYC
CAS number
2470-73-7
InChI Key
MSYUMPGNGDNTIQ-UHFFFAOYSA-N
InChI
InChI=1S/C24H33N3O2S/c1-20(18-26-12-10-25(11-13-26)14-16-29-17-15-28)19-27-21-6-2-4-8-23(21)30-24-9-5-3-7-22(24)27/h2-9,20,28H,10-19H2,1H3
IUPAC Name
2-[2-(4-{2-[(10H-phenothiazin-10-yl)methyl]propyl}piperazin-1-yl)ethoxy]ethan-1-ol
SMILES
CC(CN1CCN(CCOCCO)CC1)CN1C2=CC=CC=C2SC2=CC=CC=C12

References

General References
Not Available
ChemSpider
16265
ChEBI
135695
ChEMBL
CHEMBL3275586
Wikipedia
Dixyrazine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0327 mg/mLALOGPS
logP3.93ALOGPS
logP3.52Chemaxon
logS-4.1ALOGPS
pKa (Strongest Acidic)15.12Chemaxon
pKa (Strongest Basic)7.87Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area39.18 Å2Chemaxon
Rotatable Bond Count9Chemaxon
Refractivity126.75 m3·mol-1Chemaxon
Polarizability49.06 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-004i-0020900000-4a7a78712f7a74094867
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0013900000-5aa330406aebc0aa32c4
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0032-9236500000-444b1572e8f3416edb86
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-01tl-7009600000-341d9cd7efb06a9aa464
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0fi1-1139300000-ec0c654064d551e2df6a
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-4094000000-1fda17daebcd7904cb5d
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-188.97905
predicted
DeepCCS 1.0 (2019)
[M+H]+191.41144
predicted
DeepCCS 1.0 (2019)
[M+Na]+199.08571
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:48 / Updated at June 12, 2020 16:53