This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Vinburnine
- DrugBank Accession Number
- DB13793
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Vinburnine (DB13793)
- Weight
- Average: 294.398
Monoisotopic: 294.173213336 - Chemical Formula
- C19H22N2O
- Synonyms
- Vinburnina
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareIsosorbide mononitrate Vinburnine may increase the vasodilatory activities of Isosorbide mononitrate. Patent Blue The therapeutic efficacy of Vinburnine can be decreased when used in combination with Patent Blue. 
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- Not Available
Products
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Categories
- ATC Codes
- C04AX17 — Vinburnine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as eburnan-type alkaloids. These are alkaloids with a structure based on the eburnan skeleton, that arises from rearrangement of the aspidospermidine ring system, involving migration of C-21 from C-7 to C-2, fission of the 2,16-bond, and attachment of C-16 to N-1.
- Kingdom
- Organic compounds
- Super Class
- Alkaloids and derivatives
- Class
- Eburnan-type alkaloids
- Sub Class
- Not Available
- Direct Parent
- Eburnan-type alkaloids
- Alternative Parents
- Indolonaphthyridine alkaloids / Beta carbolines / 3-alkylindoles / Naphthyridines / Aralkylamines / Piperidines / Benzenoids / Pyrroles / Heteroaromatic compounds / Trialkylamines show 6 more
- Substituents
- 3-alkylindole / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Beta-carboline / Diazanaphthalene / Eburna alkaloid / Heteroaromatic compound show 18 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- alkaloid (CHEBI:4740) / Indole alkaloids (C09149)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- G54D0HMY25
- CAS number
- 4880-88-0
- InChI Key
- WYJAPUKIYAZSEM-MOPGFXCFSA-N
- InChI
- InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1
- IUPAC Name
- (15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.0²,⁷.0⁸,¹⁸.0¹⁵,¹⁹]nonadeca-2,4,6,8(18)-tetraen-17-one
- SMILES
- [H][C@]12N3CCC[C@@]1(CC)CC(=O)N1C4=CC=CC=C4C(CC3)=C21
References
- General References
- Not Available
- External Links
- KEGG Compound
- C09149
- ChemSpider
- 64339
- 57954
- ChEBI
- 4740
- ChEMBL
- CHEMBL1892145
- ZINC
- ZINC000019796061
- Wikipedia
- Vinburnine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Capsule, extended release Injection, solution Intramuscular - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.175 mg/mL ALOGPS logP 3.3 ALOGPS logP 2.74 Chemaxon logS -3.2 ALOGPS pKa (Strongest Acidic) 19.25 Chemaxon pKa (Strongest Basic) 6.3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 25.24 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 87.05 m3·mol-1 Chemaxon Polarizability 33.67 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available MS/MS Spectrum - , positive LC-MS/MS splash10-000b-2790000000-d9b39542541cd67b85fa
Drug created at June 23, 2017 20:48 / Updated at June 12, 2020 16:53