This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Tisopurine
- DrugBank Accession Number
- DB13807
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Tisopurine (DB13807)
- Weight
- Average: 152.18
Monoisotopic: 152.015667319 - Chemical Formula
- C5H4N4S
- Synonyms
- Tisopurine
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareBendroflumethiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Bendroflumethiazide. Benzthiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Benzthiazide. Chlorothiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Chlorothiazide. Cyclopenthiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Cyclopenthiazide. Cyclothiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Cyclothiazide. Hydrochlorothiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Hydrochlorothiazide. Hydroflumethiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Hydroflumethiazide. Polythiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Polythiazide. Trichlormethiazide The therapeutic efficacy of Tisopurine can be decreased when used in combination with Trichlormethiazide. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- ATC Codes
- M04AA02 — Tisopurine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as pyrazolo[3,4-d]pyrimidines. These are aromatic heterocyclic compounds containing a pyrazolo[3,4-d]pyrimidine ring system, which consists of a pyrazole ring fused to but and not sharing a nitrogen atom with a pyrimidine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Pyrazolopyrimidines
- Sub Class
- Pyrazolo[3,4-d]pyrimidines
- Direct Parent
- Pyrazolo[3,4-d]pyrimidines
- Alternative Parents
- Pyrimidinethiones / Pyrazoles / Heteroaromatic compounds / Azacyclic compounds / Organosulfur compounds / Organopnictogen compounds / Organonitrogen compounds / Hydrocarbon derivatives
- Substituents
- Aromatic heteropolycyclic compound / Azacycle / Azole / Heteroaromatic compound / Hydrocarbon derivative / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound / Organosulfur compound / Pyrazole
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 79F9I2R16M
- CAS number
- 5334-23-6
- InChI Key
- PYAOPMWCFSVFOT-UHFFFAOYSA-N
- InChI
- InChI=1S/C5H4N4S/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
- IUPAC Name
- 1H,4H,7H-pyrazolo[3,4-d]pyrimidine-4-thione
- SMILES
- S=C1N=CNC2=C1C=NN2
References
- General References
- Not Available
- External Links
- ChemSpider
- 580886
- 38136
- ChEBI
- 134776
- ChEMBL
- CHEMBL119423
- ZINC
- ZINC000004353300
- Wikipedia
- Tisopurine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.677 mg/mL ALOGPS logP 0 ALOGPS logP -0.12 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 8.47 Chemaxon pKa (Strongest Basic) -0.17 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 53.07 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 43.4 m3·mol-1 Chemaxon Polarizability 13.91 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:49 / Updated at February 21, 2021 18:54