Iodoform is an organoiodine compound with the formula CHI3 and a tetrahedral molecular geometry. It is a relatively water-insoluble yellow solid that is chemically reactive in free-radical reactions . Due... Due to its antimicrobial properties following topical administration, minimal levels of iodoform may be found in disinfectants and it is more primarily used for veterinary purposes.
- Mechanism
- Curator reviewed · 4 references
While the mechanism of action of iodoform remains unclear, it is proposed that iodoform releases iodine, which denatures bacterial proteins by oxidation of the free iodine. Iodoform may also play a role in chemical debridement for effective necrotic wound healing and tissue damage repair via collagen fibrinolysis; upon treatment in necrotic tissue, iodoform reduced the size of the macromolecules containing collagen I in wound surface proteins. In human gingival fibroblasts in vitro, high concentrations of iodoform was shown to decrease the viability of macrophages and epithelial cells and reduced the secretion of P. gingivalis-induced TNFα. P. gingivalis is an anaerobic bacteria present in anaerobic oral niches including periapical sites and periodontal pockets.
- Primary indication
- No approved therapeutic indications.Curator reviewed
- Formula / weight
- CHI3 · 393.732 g/mol (avg)
- First approval
- Canada, 2002
- Also known as
- carbon triiodide · Jodoform · methyl triiodide · triiodomethane
Resolves to
OKJPEAGHQZHRQV-UHFFFAOYSA-NSMILES[H]C(I)(I)IWhat you can answer from here — as of September 29, 2026
Which companies are running trials of Iodoform, in which indications and phases, and which of those programs are still active?
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