This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Calcium silicate
- DrugBank Accession Number
- DB13829
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Calcium silicate (DB13829)
- Weight
- Average: 230.288
Monoisotopic: 229.9227111 - Chemical Formula
- CaH6O8Si2
- Synonyms
- Not Available
- External IDs
- INS NO.552
- INS-552
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetaminophen Calcium silicate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy. Acetophenazine Calcium silicate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Alendronic acid The serum concentration of Alendronic acid can be decreased when it is combined with Calcium silicate. Alimemazine Calcium silicate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Calcium silicate. Amphetamine The serum concentration of Amphetamine can be increased when it is combined with Calcium silicate. Amprenavir Calcium silicate can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy. Asunaprevir Calcium silicate can cause a decrease in the absorption of Asunaprevir resulting in a reduced serum concentration and potentially a decrease in efficacy. Atazanavir Calcium silicate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy. Beclomethasone dipropionate The bioavailability of Beclomethasone dipropionate can be decreased when combined with Calcium silicate. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- ATC Codes
- A02AC02 — Calcium silicate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkaline earth metal silicates. These are inorganic compounds in which the largest oxoanion is silicate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkaline earth metal oxoanionic compounds
- Sub Class
- Alkaline earth metal silicates
- Direct Parent
- Alkaline earth metal silicates
- Alternative Parents
- Miscellaneous silicates / Metalloid salts / Inorganic oxides / Inorganic calcium salts
- Substituents
- Alkaline earth metal silicate / Inorganic calcium salt / Inorganic metalloid salt / Inorganic oxide / Inorganic salt / Silicate
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- S4255P4G5M
- CAS number
- 1344-95-2
- InChI Key
- LECAAGVQUHQAJK-UHFFFAOYSA-N
- InChI
- InChI=1S/Ca.2H3O4Si/c;2*1-5(2,3)4/h;2*1-3H/q+2;2*-1
- IUPAC Name
- calcium ditrihydrogen silicate
- SMILES
- [Ca++].O[Si](O)(O)[O-].O[Si](O)(O)[O-]
References
- General References
- Not Available
- External Links
- ChemSpider
- 32700984
- 1311526
- Wikipedia
- Calcium_silicate
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Decayed Teeth / Deep Caries / Direct Pulp Capping / Indirect Pulp Capping / Pulpitis - Reversible / Vital Pulp Therapy 1 4 Unknown Status Treatment Deep Carious Lesions / Indirect Pulp Treatment 1 2 Completed Prevention Aflatoxicosis 1 2, 3 Not Yet Recruiting Treatment Necrotic Pulp / Single Root Teeth 1 1 Unknown Status Treatment Dental Caries Extending Into Dentin 1 Not Available Completed Not Available Material, Dental / Mineral Trioxide Aggregate 1 Not Available Completed Other Deep Dental Caries 1 Not Available Completed Prevention Dental Pulp Capping 1 Not Available Not Yet Recruiting Treatment Clinical Evaluation Including Pain and Swelling 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.784 mg/mL ALOGPS logP -0.77 ALOGPS logP -2.6 Chemaxon logS -2.5 ALOGPS pKa (Strongest Acidic) 9.82 Chemaxon pKa (Strongest Basic) -4.8 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 83.75 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 9.14 m3·mol-1 Chemaxon Polarizability 6.06 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at June 23, 2017 20:49 / Updated at June 12, 2020 16:53