Calcium silicate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Calcium silicate
DrugBank Accession Number
DB13829
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 230.288
Monoisotopic: 229.9227111
Chemical Formula
CaH6O8Si2
Synonyms
Not Available
External IDs
  • INS NO.552
  • INS-552

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetaminophenCalcium silicate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetophenazineCalcium silicate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium silicate.
AlimemazineCalcium silicate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AllopurinolThe therapeutic efficacy of Allopurinol can be decreased when used in combination with Calcium silicate.
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Calcium silicate.
AmprenavirCalcium silicate can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
AsunaprevirCalcium silicate can cause a decrease in the absorption of Asunaprevir resulting in a reduced serum concentration and potentially a decrease in efficacy.
AtazanavirCalcium silicate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Beclomethasone dipropionateThe bioavailability of Beclomethasone dipropionate can be decreased when combined with Calcium silicate.
Interactions
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Food Interactions
Not Available

Categories

ATC Codes
A02AC02 — Calcium silicate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkaline earth metal silicates. These are inorganic compounds in which the largest oxoanion is silicate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkaline earth metal oxoanionic compounds
Sub Class
Alkaline earth metal silicates
Direct Parent
Alkaline earth metal silicates
Alternative Parents
Miscellaneous silicates / Metalloid salts / Inorganic oxides / Inorganic calcium salts
Substituents
Alkaline earth metal silicate / Inorganic calcium salt / Inorganic metalloid salt / Inorganic oxide / Inorganic salt / Silicate
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
S4255P4G5M
CAS number
1344-95-2
InChI Key
LECAAGVQUHQAJK-UHFFFAOYSA-N
InChI
InChI=1S/Ca.2H3O4Si/c;2*1-5(2,3)4/h;2*1-3H/q+2;2*-1
IUPAC Name
calcium ditrihydrogen silicate
SMILES
[Ca++].O[Si](O)(O)[O-].O[Si](O)(O)[O-]

References

General References
Not Available
ChemSpider
32700984
RxNav
1311526
Wikipedia
Calcium_silicate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Not Yet RecruitingTreatmentDeep Carious Lesions / Indirect Pulp Treatment1
2CompletedPreventionAflatoxicosis1
1Unknown StatusTreatmentDental Caries Extending Into Dentin1
Not AvailableCompletedNot AvailableMaterial, Dental / Mineral Trioxide Aggregate1
Not AvailableCompletedOtherDeep Dental Caries1
Not AvailableCompletedPreventionDental Pulp Capping1
Not AvailableNot Yet RecruitingTreatmentClinical Evaluation Including Pain and Swelling1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.784 mg/mLALOGPS
logP-0.77ALOGPS
logP-2.6ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)9.82ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area83.75 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity9.14 m3·mol-1ChemAxon
Polarizability6.06 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 23, 2017 20:49 / Updated on June 12, 2020 16:53