NAV

Hydroxyethylpromethazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Hydroxyethylpromethazine
DrugBank Accession Number
DB13840
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 329.48
Monoisotopic: 329.168211027
Chemical Formula
C19H25N2OS
Synonyms
  • Promethazine hydroxyethyl
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
PathwayCategory
Hydroxyethylpromethazine H1-Antihistamine ActionDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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interactions in your software
DroxidopaThe therapeutic efficacy of Droxidopa can be increased when used in combination with Hydroxyethylpromethazine.
EphedrineThe therapeutic efficacy of Ephedrine can be increased when used in combination with Hydroxyethylpromethazine.
EpinephrineThe therapeutic efficacy of Epinephrine can be increased when used in combination with Hydroxyethylpromethazine.
LevonordefrinThe therapeutic efficacy of Levonordefrin can be increased when used in combination with Hydroxyethylpromethazine.
NorepinephrineThe therapeutic efficacy of Norepinephrine can be increased when used in combination with Hydroxyethylpromethazine.
Food Interactions
Not Available

Categories

ATC Codes
R06AD05 — HydroxyethylpromethazineR06AD55 — Hydroxyethylpromethazine, combinations
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzothiazines
Sub Class
Phenothiazines
Direct Parent
Phenothiazines
Alternative Parents
Alkyldiarylamines / Diarylthioethers / Benzenoids / 1,4-thiazines / Tetraalkylammonium salts / 1,2-aminoalcohols / Azacyclic compounds / Primary alcohols / Organopnictogen compounds / Organic salts
show 2 more
Substituents
1,2-aminoalcohol / Alcohol / Alkanolamine / Alkyldiarylamine / Amine / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Benzenoid / Diarylthioether
show 16 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
571559SLAJ
CAS number
7647-63-4
InChI Key
PDSVTRQOBUIQBQ-UHFFFAOYSA-N
InChI
InChI=1S/C19H25N2OS/c1-15(21(2,3)12-13-22)14-20-16-8-4-6-10-18(16)23-19-11-7-5-9-17(19)20/h4-11,15,22H,12-14H2,1-3H3/q+1
IUPAC Name
(2-hydroxyethyl)dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]azanium
SMILES
CC(CN1C2=CC=CC=C2SC2=C1C=CC=C2)[N+](C)(C)CCO

References

General References
Not Available
Human Metabolome Database
HMDB0240229
ChemSpider
15559
ChEBI
135995
ChEMBL
CHEMBL3707371
Wikipedia
Hydroxyethylpromethazine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000583 mg/mLALOGPS
logP0.34ALOGPS
logP-0.56Chemaxon
logS-5.8ALOGPS
pKa (Strongest Acidic)13.97Chemaxon
pKa (Strongest Basic)-3.3Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area23.47 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity110.71 m3·mol-1Chemaxon
Polarizability37.44 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-01qa-9160000000-79b64763ba469372ebff
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-169.67126
predicted
DeepCCS 1.0 (2019)
[M+H]+172.02931
predicted
DeepCCS 1.0 (2019)
[M+Na]+179.15651
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:49 / Updated at June 12, 2020 16:53