Lormetazepam is a benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia. Lormatazepam is an orally available benzodiazepine used in the UK for the treatment of short-term insomnia.
- Mechanism
- Curator reviewed · 1 reference
Lormetazepam, as a benzodiazepine, binds to the regulatory site between the α and γ subunits of γ-aminobutryic acid (GABA) A receptors with γ2 and α1, α2, α3, or α5 subunits. This facilitates the opening of the chloride channel allowing chloride ions to flow into the neuron resulting in hyperpolarization. Hyperpolarized neurons require greater simulation to reach their action potential threshold. The general inhibitory effect on neuronal depolarization produces the effects of lormetazepam.
- Primary indication
- For the treatment of short-term insomniaCurator reviewed · 4 structured indications
- Formula / weight
- C16H12Cl2N2O2 · 335.185 g/mol (avg)
- Also known as
- (RS)-Lormetazepam · Methyllorazepam · N-Methyllorazepam
Resolves to
FJIKWRGCXUCUIG-UHFFFAOYSA-NSMILESCN1C2=C(C=C(Cl)C=C2)C(=NC(O)C1=O)C1=CC=CC=C1ClWhat you can answer from here — as of May 21, 2021
Which other approved drugs treat the same conditions as Lormetazepam, and which companies have late-stage candidates in those indications?
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