Human cytomegalovirus immune globulin is a solution of immune globulin G against cytomegalovirus used to prevent transmission of cytomegalovirus after organ transplants. Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV).
- Mechanism
- Curator reviewed · 2 references
CMV—IGIV mainly consists of immunoglobulin G (IgG), specifically subclasses IgG1 and IgG3. IgG1 and IgG3 play important roles in viral neutralization in addition to tissue protection and complement activation.
Immunoglobulins, such as CMV-IGIV, inhibit extracellular viruses from infecting their specific target cells. Viral neutralization decreases the capacity of viruses to spread from an extracellular location to an intracellular location. CMV-IGIV inhibits infection of cells with CMV due to the fact that the virus is prevented from accessing key cell membrane targets, or because of interference with uncoating or entry. Cytogam inhibits these process.
- Primary indication
- It is used to prevent cytomegalovirus (CMV) disease after organ transplant.Curator reviewed · 2 structured indications
- First approval
- Canada, 2022 · United States, 2009
- Also known as
- CMV-immune globulin · CMVIG · Cytomegalovirus immune globulin (human) · Cytomegalovirus immunoglobulin · Human cytomegalovirus immunoglobulin
- Brand names
Resolves to
What you can answer from here — as of May 20, 2025
Which other approved drugs treat the same conditions as Human cytomegalovirus immune globulin, and which companies have late-stage candidates in those indications?
Create a free account or log in to explore the full data card.
Create Account